Association Analysis of Premature Coronary Artery Disease and Cytochrome P450 2D6 (Cyp2d6) C100t and G1846a Genetic Variants and Haplotypes in Iranian Population

Association Analysis of Premature Coronary Artery Disease and Cytochrome P450 2D6 (Cyp2d6) C100t and G1846a Genetic Variants and Haplotypes in Iranian Population Publisher

Bahiraee A¹ ; Nejatizadeh A¹ ; Farshidi H² ; Malekzadeh K¹ ; Emamgholipour S³ ; Ebrahimi R^{3, 4} ; Aghabozorgi AS⁵ ; Yazdany M¹ ; Shekari M¹

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1. Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2. Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Medical Genetics Research Center, Basic Medical Sciences Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Meta Gene Published:2020

Abstract

Background: Premature coronary artery disease (pCAD) is a heterogeneous disease affected by both genetic and environmental determinants. Cytochrome P450 2D6 (CYP2D6) enzyme plays an important role in the oxidation of drugs and inactivation of reactive species. Therefore, polymorphisms in CYP2D6 may lead to an increased susceptibility to pCAD. Here, we analyzed the association between C100T and G1846A polymorphisms of CYP2D6 gene with pCAD in a south Iranian population. Methods: Men under 45 and women under 55 years old enrolled in this study as 168 pCAD patients and 167 controls. Clinical characteristics of participants were assessed thorough clinical examination. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was applied for C100T and G1846A polymorphisms. Results: The results indicated that the history of smoking and hypertension were significantly associated with the incidence of pCAD (p < .05). However, results showed that allelic frequencies for none of the study polymorphisms in CYP2D6 were different between case and control groups. Furthermore, they were not associated with the risk of pCAD development in the study population. To better diagnosis of the molecular genetic basis of pCAD as a complex disease, this study used two-locus haplotypes of CYP2D6 polymorphisms as novel biomarkers for pCAD for the first time which also did not show a significant result. Conclusion: This study demonstrated no significant association of C100T and G1846A polymorphisms of CYP2D6 with pCAD in the south Iranian population. The possible explanation may be attributed to the differences in dissimilar ethnic, genetic, and environmental backgrounds, and also different sample sizes. © 2020

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Style	Citing Format
MLA	Bahiraee A, et al.. "Association Analysis of Premature Coronary Artery Disease and Cytochrome P450 2D6 (Cyp2d6) C100t and G1846a Genetic Variants and Haplotypes in Iranian Population." Meta Gene, vol. 25, no. , 2020, pp. -.
APA	Bahiraee A, Nejatizadeh A, Farshidi H, Malekzadeh K, Emamgholipour S, Ebrahimi R, Aghabozorgi AS, Yazdany M, Shekari M (2020). Association Analysis of Premature Coronary Artery Disease and Cytochrome P450 2D6 (Cyp2d6) C100t and G1846a Genetic Variants and Haplotypes in Iranian Population. Meta Gene, 25(), -.
Chicago	Bahiraee A, Nejatizadeh A, Farshidi H, Malekzadeh K, Emamgholipour S, Ebrahimi R, Aghabozorgi AS, Yazdany M, Shekari M. "Association Analysis of Premature Coronary Artery Disease and Cytochrome P450 2D6 (Cyp2d6) C100t and G1846a Genetic Variants and Haplotypes in Iranian Population." Meta Gene 25, no. (2020): -.
Harvard	Bahiraee A et al. (2020) 'Association Analysis of Premature Coronary Artery Disease and Cytochrome P450 2D6 (Cyp2d6) C100t and G1846a Genetic Variants and Haplotypes in Iranian Population', Meta Gene, 25(), pp. -.
Vancouver	Bahiraee A, Nejatizadeh A, Farshidi H, Malekzadeh K, Emamgholipour S, Ebrahimi R, et al.. Association Analysis of Premature Coronary Artery Disease and Cytochrome P450 2D6 (Cyp2d6) C100t and G1846a Genetic Variants and Haplotypes in Iranian Population. Meta Gene. 2020;25():-.
BibTex	@article{ author = {Bahiraee A and Nejatizadeh A and Farshidi H and Malekzadeh K and Emamgholipour S and Ebrahimi R and Aghabozorgi AS and Yazdany M and Shekari M}, title = {Association Analysis of Premature Coronary Artery Disease and Cytochrome P450 2D6 (Cyp2d6) C100t and G1846a Genetic Variants and Haplotypes in Iranian Population}, journal = {Meta Gene}, volume = {25}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Bahiraee A AU - Nejatizadeh A AU - Farshidi H AU - Malekzadeh K AU - Emamgholipour S AU - Ebrahimi R AU - Aghabozorgi AS AU - Yazdany M AU - Shekari M TI - Association Analysis of Premature Coronary Artery Disease and Cytochrome P450 2D6 (Cyp2d6) C100t and G1846a Genetic Variants and Haplotypes in Iranian Population JO - Meta Gene VL - 25 IS - SP - EP - PY - 2020 ER -

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