Angiotensin-Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings

Angiotensin-Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings Publisher Pubmed

Monajemzadeh M¹ ; Hesami M¹ ; Shahsiah R¹ ; Vasei M¹ ; Hooshmand S¹ ; Tanzifi P¹ ; Hajizadeh N¹ ; Ataei N¹ ; Mehrkash M¹ ; Javadi Larijani F¹ ; Moghtaderi M¹ ; Bazargani B¹ ; Khorvash R¹ ; Soleimanifar N¹

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1. Tehran University of Medical Sciences, Pathology, Tehran, Iran

Source: Fetal and Pediatric Pathology Published:2017

Abstract

Objective: Angiotensin converting enzyme (ACE) converts angiotensin I into angiotensin II. The ACE gene shows an I/D polymorphism, which correlates with ACE concentrations. The aim of this study is to evaluate the distribution of the ACE I/D genotype in children with idiopathic nephrotic syndrome (INS) and healthy controls and study the effect of this polymorphism on clinical and pathologic findings. Methods: ACE gene I/D polymorphism of 104 patients with INS and 119 controls were determined. Results: The DD, ID, and II genotypes were found in 58.7%, 22.1%, and 19.2% of the patients, and in 79.8%, 2.5%, and 17.6% of controls, respectively (p > 0.05). The ID genotype was seen more frequently in patients resistant to treatment. Conclusion: The observed differences with previous reports suggest the influence of the genetic background on disease course. The ACE I/D gene polymorphism's role seems to be more important in renal disease progression than susceptibility. © 2017 Taylor & Francis Group, LLC.

Style	Citing Format
MLA	Monajemzadeh M, et al.. "Angiotensin-Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings." Fetal and Pediatric Pathology, vol. 36, no. 4, 2017, pp. 265-275.
APA	Monajemzadeh M, Hesami M, Shahsiah R, Vasei M, Hooshmand S, Tanzifi P, Hajizadeh N, Ataei N, Mehrkash M, Javadi Larijani F, Moghtaderi M, Bazargani B, Khorvash R, Soleimanifar N (2017). Angiotensin-Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings. Fetal and Pediatric Pathology, 36(4), 265-275.
Chicago	Monajemzadeh M, Hesami M, Shahsiah R, Vasei M, Hooshmand S, Tanzifi P, Hajizadeh N, et al.. "Angiotensin-Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings." Fetal and Pediatric Pathology 36, no. 4 (2017): 265-275.
Harvard	Monajemzadeh M et al. (2017) 'Angiotensin-Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings', Fetal and Pediatric Pathology, 36(4), pp. 265-275.
Vancouver	Monajemzadeh M, Hesami M, Shahsiah R, Vasei M, Hooshmand S, Tanzifi P, et al.. Angiotensin-Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings. Fetal and Pediatric Pathology. 2017;36(4):265-275.
BibTex	@article{ author = {Monajemzadeh M and Hesami M and Shahsiah R and Vasei M and Hooshmand S and Tanzifi P and Hajizadeh N and Ataei N and Mehrkash M and Javadi Larijani F and Moghtaderi M and Bazargani B and Khorvash R and Soleimanifar N}, title = {Angiotensin-Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings}, journal = {Fetal and Pediatric Pathology}, volume = {36}, number = {4}, pages = {265-275}, year = {2017} }
RIS	TY - JOUR AU - Monajemzadeh M AU - Hesami M AU - Shahsiah R AU - Vasei M AU - Hooshmand S AU - Tanzifi P AU - Hajizadeh N AU - Ataei N AU - Mehrkash M AU - Javadi Larijani F AU - Moghtaderi M AU - Bazargani B AU - Khorvash R AU - Soleimanifar N TI - Angiotensin-Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome, Effect on Biopsy Findings JO - Fetal and Pediatric Pathology VL - 36 IS - 4 SP - 265 EP - 275 PY - 2017 ER -

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