Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Success in Tooth Bud Regeneration: A Short Communication Publisher Pubmed



Sadrabad MJ1, 2 ; Saberian E3 ; Izadi A4 ; Emami R5 ; Ghadyani F6
Authors

Source: Journal of Endodontics Published:2024


Abstract

Introduction: Tooth caries and loss are frequent clinical diseases in dentistry. Tissue engineering is a new therapeutic choice for the complete biological regeneration of pulpal and dental tissues in regenerative dentistry. The aim of this study was to establish a protocol for in situ regeneration of a dental bud in the extracted socket. Methods: The current study examined tooth bud regeneration with dental pulp stem cells induced by a dentin derivative signal in a rabbit's jaw. Result: A tooth bud was regenerated; the morphology and structure of it were typical, and it was post–Bell stage. Conclusions: In our study, a real tooth bud was formed in the post–Bell stage with complete morphologic and biological features. However, the application of this method for tooth regeneration in humans necessitates further research. © 2023 American Association of Endodontists
Related Docs
View other Related Docs
1. The Role of Stem Cell Therapy in Regeneration of Dentine-Pulp Complex: A Systematic Review, Progress in Biomaterials (2018)
2. Cell Homing Strategy As a Promising Approach to the Vitality of Pulp-Dentin Complexes in Endodontic Therapy: Focus on Potential Biomaterials, Expert Opinion on Biological Therapy (2022)
3. Tissue Engineering: Dentin – Pulp Complex Regeneration Approaches (A Review), Tissue and Cell (2017)
Experts (# of related papers)
View all Related Experts
Mohammad Hossein Nekoofar (4)
Reza Masaeli (1)
Other Related Docs
4. Advances in Scaffolds Used for Pulp–Dentine Complex Tissue Engineering: A Narrative Review, International Endodontic Journal (2022)
5. Effects of Combining Hyaluronic Acid Hydrogel With Injectable Platelet Rich Fibrin on Apical Papilla Stem Cells Proliferation and Differentiation, BMC Oral Health (2025)
6. Application of Biocompatible Scaffolds in Stem-Cell-Based Dental Tissue Engineering, Advances in Experimental Medicine and Biology (2023)
7. Mapping Global Research in Dental Pulp Regeneration: A 10‑Year Bibliometric Analysis, Dental Research Journal (2024)
8. Regenerative Property of Prf Used As Capping Material in Pulpotomy in Dogs, Biomedical Research (India) (2017)
9. Histologic Tissue Response to Furcation Perforation Repair Using Mineral Trioxide Aggregate or Dental Pulp Stem Cells Loaded Onto Treated Dentin Matrix or Tricalcium Phosphate, Clinical Oral Investigations (2017)
10. Different Methods of Dentin Processing for Application in Bone Tissue Engineering: A Systematic Review, Journal of Biomedical Materials Research - Part A (2016)
11. Potential of Treated Dentin Matrix Xenograft for Dentin-Pulp Tissue Engineering, Journal of Endodontics (2020)
12. Comparative Effects of Er:Yag Laser, and Edta, Mtad, and Qmix Irrigants on Adhesion of Stem Cells From the Apical Papilla to Dentin: A Scanning Electron Microscopic Study, Journal of Clinical and Experimental Dentistry (2022)
13. Fracture Strength and Three-Dimensional Marginal Evaluation of Biocompatible High-Performance Polymer Versus Pressed Lithium Disilicate Crowns, Journal of Prosthetic Dentistry (2023)
14. Application of Periodontal Ligament Stem Cells in Periodontal Regeneration: A Systematic Review, Journal of Applied Biotechnology Reports (2023)
15. Evaluation of the Effects of 810 Nm Diode Laser Alone and in Combination With Gluma© and Chromophore on Dentinal Tubule Occlusion: A Scanning Electron Microscopic Analysis, Journal of Lasers in Medical Sciences (2020)
16. Comparison of the Effect of Qmix and Conventional Root Canal Irrigants on Push-Out Bond Strength of Fiber Post to Root Dentin, Clinical and Experimental Dental Research (2022)
17. The Development of a Dental Light Curable Prfe-Loaded Hydrogel As a Potential Scaffold for Pulp-Dentine Complex Regeneration: An in Vitro Study, International Endodontic Journal (2023)
18. Evaluation of Gutta-Percha-Filled Areas in Curved and Straight Root Canals Using Three Reciprocating Single-File Systems Followed by Matching Single-Cone Obturation, Applied Sciences (Switzerland) (2024)
19. Using Enamel Matrix Derivative to Improve Treatment Efficacy in Periodontal Furcation Defects, Journal of Prosthodontics (2018)
20. Screw-Assisted Soft Tissue Stabilization - a Paradigm Shift in Flap Fixation: A Case Series With a 3 Months Follow-Up, Dental Hypotheses (2018)