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Reducing the Risk of Death Induced by Aluminum Phosphide Poisoning: The New Therapies Publisher Pubmed



Naddafi M1, 2 ; Mehrizi AA3 ; Eghbal MA1, 4 ; Khansari MG5 ; Azarmi Y1 ; Sattari MR1 ; Karaman C6 ; Karimi F7 ; Alizadeh M8, 9 ; Yazdani MN9 ; Hosseinpour P10
Authors
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Authors Affiliations
  1. 1. Pharmacology and Toxicology Department, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. School of Physics, University of Electronic Science and Technology of China, Chengdu, 610054, China
  4. 4. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Akdeniz University, Department of Electricity and Energy, Antalya, 07070, Turkey
  7. 7. Department of Chemical Engineering, Quchan University of Technology, Quchan, 9477177870, Iran
  8. 8. Pharmeceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  9. 9. Laboratory of Basic Sciences, Mohammad Rasul Allah Research Tower, Shiraz University of Medical Sciences, PO Box: 71348-14336, Shiraz, Iran
  10. 10. Department of Materials Science and Engineering, Sharif University of Technology, Tehran, Iran

Source: Chemosphere Published:2022


Abstract

Numerous people suffer from accidental or deliberate exposure to different pesticides when poisoning with aluminum phosphate (AlP) is increasing in the eastern countries. Aluminum phosphate is a conventional insecticide that quickly reacts with water or the moistures in the atmosphere and produces fatal phosphine gas, which absorbs quickly by the body. Oral consumption or inhalation of AlP leads to excessive reaction of the body such as fatigue, vomiting, fever, palpitation, vasodilatory shock, increasing blood pressure, cardiac dysfunction, pulmonary congestion, shortness of breath, and death. The garlic smell from the patient's mouth or exhale is one of the methods to recognize the positioning. Due to the lack of individual antidotes, several supportive treatments are required. The present study focused on the available and new therapies that help reduce the effect of AlP poisoning and the mortality rate. The therapies are divided into the antioxidant-related agent and the other agents. The impacts of each agent on the experimental cases are reported. © 2022 Elsevier Ltd
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