Therapeutic Effects of Oral Liothyronine on Aluminum Phosphide Poisoning As an Adjuvant Therapy: A Clinical Trial Publisher Pubmed



Goharbari MH¹ ; Taghaddosinejad F² ; Arefi M³ ; Sharifzadeh M¹ ; Mojtahedzadeh M⁴ ; Nikfar S⁵ ; Baeeri M¹ ; Rahimifard M¹ ; Abdollahi M^{1, 6} Show Affiliations
Source: Human and Experimental Toxicology Published:2018

Abstract

Background: In aluminum phosphide (AlP) poisoning, death is mainly due to cardiovascular failure and refractory acute heart failure. There is a lot of evidence showing thyroid hormones have cardioprotective effects. Objective: The purpose of this study was to evaluate the effect of oral liothyronine in the treatment of AlP poisoning. Methods: Twenty-four patients from intensive care unit of Baharloo Hospital, Tehran, Iran, were included based on the inclusion and exclusion criteria. They were randomly divided into two parallel groups of 12 cases and 12 controls. Intervention in the case group was administration of 50 μg liothyronine via nasogastric tube after gastric lavage, in the first 6 h of poisoning. In both groups, the routine treatment of AlP poisoning was performed. Blood samples were prepared at the beginning of the study and after 12 h. Patients were followed up till discharge from the hospital or death. Results: The findings demonstrated that oral liothyronine was able to significantly improve systolic blood pressure, arterial blood pH, and total thiol molecules and also could decrease lipid peroxidation, increase catalase activity, and prevent further decline in total antioxidant capacity. Conclusion: Liothyronine administration is effective in controlling AlP poisoning and can improve patients’ outcome. © The Author(s) 2017.