The Effect of Family Structure on the Still-Missing Heritability and Genomic Prediction Accuracy of Type 2 Diabetes

The Effect of Family Structure on the Still-Missing Heritability and Genomic Prediction Accuracy of Type 2 Diabetes Publisher Pubmed

Amiri Roudbar M¹ ; Vahedi SM³ ; Jin J⁴ ; Jahangiri M⁵ ; Lanjanian H⁶ ; Habibi D^{6, 17} ; Masjoudi S⁶ ; Riahi P⁶ ; Fateh ST⁷ ; Neshati F⁶ ; Zahedi AS⁶ ; Moazzamjazi M⁶ ; Najdhassanbonab L⁶ ; Mousavi SF⁸ Show All Authors

Amiri Roudbar M¹
Vahedi SM³
Jin J⁴
Jahangiri M⁵
Lanjanian H⁶
Habibi D^{6, 17}
Masjoudi S⁶
Riahi P⁶
Fateh ST⁷
Neshati F⁶
Zahedi AS⁶
Moazzamjazi M⁶
Najdhassanbonab L⁶
Mousavi SF⁸
Asgarian S⁶
Zarkesh M⁶
Moghaddas MR⁶
Tenesa A^{9, 10}
Kazemnejad A⁵
Vahidnezhad H^{11, 12, 13}
Hakonarson H^{11, 12, 13, 14, 15}
Azizi F¹⁶
Hedayati M⁶
Daneshpour MS⁶
Akbarzadeh M⁶

Show Affiliations

1. Department of Animal Science, Safiabad-Dezful Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education & amp
2. Extension Organization, Dezful, Iran
3. Department of Animal Science and Aquaculture, Dalhousie University, Bible Hill, B2N5E3, NS, Canada
4. Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, United States
5. Department of Biostatistics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
6. Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
8. Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
9. MRC Human Genetics Unit, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, United Kingdom
10. The Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian, United Kingdom
11. Center for Applied Genomics (CAG), Children’s Hospital of Philadelphia, 3615 Civic Center Blvd, Abramson Building, Philadelphia, 19104, PA, United States
12. Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, PA, United States
13. Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, 19104, PA, United States
14. Division of Pulmonary Medicine, Children’s Hospital of Philadelphia, Philadelphia, 19104, PA, United States
15. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
16. Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
17. Department of Biostatistics and Epidemiology School of Public Health, Babol University of Medical Sciences, Babol, Iran

Source: Human Genomics Published:2024

Abstract

This study aims to assess the effect of familial structures on the still-missing heritability estimate and prediction accuracy of Type 2 Diabetes (T2D) using pedigree estimated risk values (ERV) and genomic ERV. We used 11,818 individuals (T2D cases: 2,210) with genotype (649,932 SNPs) and pedigree information from the ongoing periodic cohort study of the Iranian population project. We considered three different familial structure scenarios, including (i) all families, (ii) all families with ≥ 1 generation, and (iii) families with ≥ 1 generation in which both case and control individuals are presented. Comprehensive simulation strategies were implemented to quantify the difference between estimates of and. A proportion of still-missing heritability in T2D could be explained by overestimation of pedigree-based heritability due to the presence of families with individuals having only one of the two disease statuses. Our research findings underscore the significance of including families with only case/control individuals in cohort studies. The presence of such family structures (as observed in scenarios i and ii) contributes to a more accurate estimation of disease heritability, addressing the underestimation that was previously overlooked in prior research. However, when predicting disease risk, the absence of these families (as seen in scenario iii) can yield the highest prediction accuracy and the strongest correlation with Polygenic Risk Scores. Our findings represent the first evidence of the important contribution of familial structure for heritability estimations and genomic prediction studies in T2D. © The Author(s) 2024.

2. The Importance of Precision Medicine in Type 2 Diabetes Mellitus (T2dm): From Pharmacogenetic and Pharmacoepigenetic Aspects, Endocrine# Metabolic and Immune Disorders - Drug Targets (2019)

3. Multivariate and Gene-Based Association Testing of Sarcopenia: Bushehr Elderly Health Program (Beh), Journal of Biostatistics and Epidemiology (2022)

4. Whole-Genome Sequencing Reveals Host Factors Underlying Critical Covid-19, Nature (2022)

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Mohammad Reza Mohajeri Tehrani (1)

Noushin Fahimfar (1)

Style	Citing Format
MLA	Amiri Roudbar M, et al.. "The Effect of Family Structure on the Still-Missing Heritability and Genomic Prediction Accuracy of Type 2 Diabetes." Human Genomics, vol. 18, no. 1, 2024, pp. -.
APA	Amiri Roudbar M, Vahedi SM, Jin J, Jahangiri M, Lanjanian H, Habibi D, Masjoudi S, Riahi P, Fateh ST, Neshati F, Zahedi AS, Moazzamjazi M, Najdhassanbonab L, Mousavi SF, Asgarian S, Zarkesh M, Moghaddas MR, Tenesa A, Kazemnejad A, ... Akbarzadeh M (2024). The Effect of Family Structure on the Still-Missing Heritability and Genomic Prediction Accuracy of Type 2 Diabetes. Human Genomics, 18(1), -.
Chicago	Amiri Roudbar M, Vahedi SM, Jin J, Jahangiri M, Lanjanian H, Habibi D, Masjoudi S, et al.. "The Effect of Family Structure on the Still-Missing Heritability and Genomic Prediction Accuracy of Type 2 Diabetes." Human Genomics 18, no. 1 (2024): -.
Harvard	Amiri Roudbar M et al. (2024) 'The Effect of Family Structure on the Still-Missing Heritability and Genomic Prediction Accuracy of Type 2 Diabetes', Human Genomics, 18(1), pp. -.
Vancouver	Amiri Roudbar M, Vahedi SM, Jin J, Jahangiri M, Lanjanian H, Habibi D, et al.. The Effect of Family Structure on the Still-Missing Heritability and Genomic Prediction Accuracy of Type 2 Diabetes. Human Genomics. 2024;18(1):-.
BibTex	@article{ author = {Amiri Roudbar M and Vahedi SM and Jin J and Jahangiri M and Lanjanian H and Habibi D and Masjoudi S and Riahi P and Fateh ST and Neshati F and Zahedi AS and Moazzamjazi M and Najdhassanbonab L and Mousavi SF and Asgarian S and Zarkesh M and Moghaddas MR and Tenesa A and Kazemnejad A and Vahidnezhad H and Hakonarson H and Azizi F and Hedayati M and Daneshpour MS and Akbarzadeh M}, title = {The Effect of Family Structure on the Still-Missing Heritability and Genomic Prediction Accuracy of Type 2 Diabetes}, journal = {Human Genomics}, volume = {18}, number = {1}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Amiri Roudbar M AU - Vahedi SM AU - Jin J AU - Jahangiri M AU - Lanjanian H AU - Habibi D AU - Masjoudi S AU - Riahi P AU - Fateh ST AU - Neshati F AU - Zahedi AS AU - Moazzamjazi M AU - Najdhassanbonab L AU - Mousavi SF AU - Asgarian S AU - Zarkesh M AU - Moghaddas MR AU - Tenesa A AU - Kazemnejad A AU - Vahidnezhad H AU - Hakonarson H AU - Azizi F AU - Hedayati M AU - Daneshpour MS AU - Akbarzadeh M TI - The Effect of Family Structure on the Still-Missing Heritability and Genomic Prediction Accuracy of Type 2 Diabetes JO - Human Genomics VL - 18 IS - 1 SP - EP - PY - 2024 ER -

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