A Chitosan-Based Hydrogel Containing Zinc Oxide Nanoparticles As a Carrier for Improving Antibacterial Activity and Controlling the Release of Antibiotics

A Chitosan-Based Hydrogel Containing Zinc Oxide Nanoparticles As a Carrier for Improving Antibacterial Activity and Controlling the Release of Antibiotics Publisher

Rastegari A¹ ; Hasanshakir F¹ ; Mohammadi Z¹ ; Saadatpor F² ; Faghihi H¹ ; Moraffah F³

Show Affiliations

1. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Iran University of Medical Sciences, Tehran, Iran
2. Molecular Virology Lab, Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, Iran
3. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Micro and Nano Letters Published:2023

Abstract

Microbial infections are considered one of the most important concerns of the world community. Developing drug delivery systems based on formulation of nanoparticles (NPs) with antimicrobial agents has shown beneficial effectiveness against microbial infections and related antimicrobial resistance. In this study, the authors prepared and characterized a chitosan-based hydrogel loaded with zinc oxide NPs for controlling the release of vancomycin and also improving its antibacterial effect. Characterization studies demonstrated that the developed biopolymeric hydrogel was able to sustain and control the release of vancomycin in response to acidic media for 96 h. Furthermore, antimicrobial studies showed significant and efficient antibacterial activity of prepared hydrogel against Staphylococcus aureus and Pseudomonas aeruginosa. Based on the obtained results, it can be concluded that the prepared chitosan hydrogel (CH) containing zinc oixde (ZnO) NPs has a desirable activity for controlling the release of vancomycin and improving its antibacterial properties. © 2023 The Authors. Micro & Nano Letters published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.

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Style	Citing Format
MLA	Rastegari A, et al.. "A Chitosan-Based Hydrogel Containing Zinc Oxide Nanoparticles As a Carrier for Improving Antibacterial Activity and Controlling the Release of Antibiotics." Micro and Nano Letters, vol. 18, no. 7, 2023, pp. -.
APA	Rastegari A, Hasanshakir F, Mohammadi Z, Saadatpor F, Faghihi H, Moraffah F (2023). A Chitosan-Based Hydrogel Containing Zinc Oxide Nanoparticles As a Carrier for Improving Antibacterial Activity and Controlling the Release of Antibiotics. Micro and Nano Letters, 18(7), -.
Chicago	Rastegari A, Hasanshakir F, Mohammadi Z, Saadatpor F, Faghihi H, Moraffah F. "A Chitosan-Based Hydrogel Containing Zinc Oxide Nanoparticles As a Carrier for Improving Antibacterial Activity and Controlling the Release of Antibiotics." Micro and Nano Letters 18, no. 7 (2023): -.
Harvard	Rastegari A et al. (2023) 'A Chitosan-Based Hydrogel Containing Zinc Oxide Nanoparticles As a Carrier for Improving Antibacterial Activity and Controlling the Release of Antibiotics', Micro and Nano Letters, 18(7), pp. -.
Vancouver	Rastegari A, Hasanshakir F, Mohammadi Z, Saadatpor F, Faghihi H, Moraffah F. A Chitosan-Based Hydrogel Containing Zinc Oxide Nanoparticles As a Carrier for Improving Antibacterial Activity and Controlling the Release of Antibiotics. Micro and Nano Letters. 2023;18(7):-.
BibTex	@article{ author = {Rastegari A and Hasanshakir F and Mohammadi Z and Saadatpor F and Faghihi H and Moraffah F}, title = {A Chitosan-Based Hydrogel Containing Zinc Oxide Nanoparticles As a Carrier for Improving Antibacterial Activity and Controlling the Release of Antibiotics}, journal = {Micro and Nano Letters}, volume = {18}, number = {7}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Rastegari A AU - Hasanshakir F AU - Mohammadi Z AU - Saadatpor F AU - Faghihi H AU - Moraffah F TI - A Chitosan-Based Hydrogel Containing Zinc Oxide Nanoparticles As a Carrier for Improving Antibacterial Activity and Controlling the Release of Antibiotics JO - Micro and Nano Letters VL - 18 IS - 7 SP - EP - PY - 2023 ER -

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