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Antibacterial Activity of Chitosan-Based Nanohybrid Membranes Against Drug-Resistant Bacterial Isolates From Burn Wound Infections Publisher Pubmed



Amiri P1 ; Kardanyamchi J2, 3 ; Kazemian H4, 5 ; Rezaei F6
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  3. 3. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Microbiology, School of Medicine, Ilam University of Medical Sciences, Tehran, Iran
  5. 5. Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran
  6. 6. Department of Microbiology, School of Medicine, Lorestan University of Medical Sciences, Moallem Street, Khorramabad, Iran

Source: Archives of Microbiology Published:2022


Abstract

Biocompatible and non-toxic properties of chitosan make it a candidate with excellent application prospects in developing wound dressing conjugate compounds. Six different chitosan-based nanohybrid membranes were evaluated against multidrug-resistant bacterial isolates. Different combinations of chitosan, ciprofloxacin (CIP), biofunctionalized montmorillonite (MMT), and montmorillonite with sulfate chains (SMMT) were provided, and their antibacterial activity was assessed using the colony count method. Totally, 27 drug-resistant isolates, including 6x methicillin-resistant Staphylococcus aureus, 7 vancomycin-resistant Enterococcus faecalis, 4 Acinetobacterbaumannii, and 10 Pseudomonas aeruginosa isolates were identified from burn wound infections. Chitosan and montmorillonite did not show significant antibacterial effect (p > 0.05), but chitosan/SMMT/CIP was the most effective nanocomposite (p < 0.01). Chitosan-based nanocomposites with ciprofloxacin could effectively reduce the susceptibility of drug-resistant bacterial isolates. Bacterial targeting using nanosystems provides an opportunity for effective antibiotic treatment by improving antibacterial efficacy. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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1. Biofilm Formation and Antibiotic Resistance in Meticillin-Resistant and Meticillin-Sensitive Staphylococcus Aureus Isolated From Burns, Journal of Wound Care (2019)
2. The Anti-Biofilm Capability of Nano-Emodin-Mediated Sonodynamic Therapy on Multi-Species Biofilms Produced by Burn Wound Bacterial Strains, Photodiagnosis and Photodynamic Therapy (2021)
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