Local Delivery of Linezolid Via Chitosan-Gelatin Hydrogel Coated Orthopedic Implants As a Promising Strategy for Treatment of Implant-Associated Infections

Local Delivery of Linezolid Via Chitosan-Gelatin Hydrogel Coated Orthopedic Implants As a Promising Strategy for Treatment of Implant-Associated Infections Publisher Pubmed

Gholami M ; Rezaei M ; Zahraei M ; Dorkoosh FA ; Samani MK ; Keykhaee M ; Aghazadeh E ; Karami Z ; Handali S

Source: International Journal of Biological Macromolecules Published:2026

Abstract

Implant-related infections are a serious complication caused by the colonization of bacteria on the surface of surgical implants. These infections can reduce the durability of implants and lead to additional surgeries to replace them. Local antibiotic therapy has received increasing attention for preventing and treating infections related to implants. The purpose of this study was to develop a biocompatible and crosslinker-free chitosan-gelation hydrogel impregnated with linezolid (CS-Gel-LZD) as a promising local delivery system for combating implant-associated infections. The resulting hydrogel exhibited potent antibacterial activity, excellent biodegradability and high cytocompatibility and hemocompatibility. The hydrogel also provided a prolonged releasing profile for LZD, approximately 4 days. In the in vivo study, CS-Gel-LZD displayed significantly higher clearance of bacteria than CS-Gel hydrogel without LZD in infected bone and surrounding tissues. Furthermore, radiographic imaging and pathology analysis exhibited no signs of infections in the CS-Gel-LZD treated group. According to these findings, incorporation of LZD in the CS-Gel hydrogel could be a promising platform for preventing and treating implant-associated infections. © 2025 Elsevier B.V.

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Style	Citing Format
MLA	Gholami M, et al.. "Local Delivery of Linezolid Via Chitosan-Gelatin Hydrogel Coated Orthopedic Implants As a Promising Strategy for Treatment of Implant-Associated Infections." International Journal of Biological Macromolecules, vol. 339, no. , 2026, pp. -.
APA	Gholami M, Rezaei M, Zahraei M, Dorkoosh FA, Samani MK, Keykhaee M, Aghazadeh E, Karami Z, Handali S (2026). Local Delivery of Linezolid Via Chitosan-Gelatin Hydrogel Coated Orthopedic Implants As a Promising Strategy for Treatment of Implant-Associated Infections. International Journal of Biological Macromolecules, 339(), -.
Chicago	Gholami M, Rezaei M, Zahraei M, Dorkoosh FA, Samani MK, Keykhaee M, Aghazadeh E, Karami Z, Handali S. "Local Delivery of Linezolid Via Chitosan-Gelatin Hydrogel Coated Orthopedic Implants As a Promising Strategy for Treatment of Implant-Associated Infections." International Journal of Biological Macromolecules 339, no. (2026): -.
Harvard	Gholami M et al. (2026) 'Local Delivery of Linezolid Via Chitosan-Gelatin Hydrogel Coated Orthopedic Implants As a Promising Strategy for Treatment of Implant-Associated Infections', International Journal of Biological Macromolecules, 339(), pp. -.
Vancouver	Gholami M, Rezaei M, Zahraei M, Dorkoosh FA, Samani MK, Keykhaee M, et al.. Local Delivery of Linezolid Via Chitosan-Gelatin Hydrogel Coated Orthopedic Implants As a Promising Strategy for Treatment of Implant-Associated Infections. International Journal of Biological Macromolecules. 2026;339():-.
BibTex	@article{ author = {Gholami M and Rezaei M and Zahraei M and Dorkoosh FA and Samani MK and Keykhaee M and Aghazadeh E and Karami Z and Handali S}, title = {Local Delivery of Linezolid Via Chitosan-Gelatin Hydrogel Coated Orthopedic Implants As a Promising Strategy for Treatment of Implant-Associated Infections}, journal = {International Journal of Biological Macromolecules}, volume = {339}, number = {}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Gholami M AU - Rezaei M AU - Zahraei M AU - Dorkoosh FA AU - Samani MK AU - Keykhaee M AU - Aghazadeh E AU - Karami Z AU - Handali S TI - Local Delivery of Linezolid Via Chitosan-Gelatin Hydrogel Coated Orthopedic Implants As a Promising Strategy for Treatment of Implant-Associated Infections JO - International Journal of Biological Macromolecules VL - 339 IS - SP - EP - PY - 2026 ER -

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