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Fish Consumption and Gastric Cancer Within the Stomach Cancer Pooling (Stop) Project Publisher Pubmed



Franchi C1, 2 ; Ardoino I1 ; Mandelli S1 ; Patel L3 ; Pelucchi C3 ; Bonzi R3 ; Camargo MC4 ; Rabkin CS4 ; Liao LM4 ; Sinha R4 ; Johnson KC5 ; Hu J6 ; Zhang ZF7 ; Palli D8 Show All Authors
Authors
  1. Franchi C1, 2
  2. Ardoino I1
  3. Mandelli S1
  4. Patel L3
  5. Pelucchi C3
  6. Bonzi R3
  7. Camargo MC4
  8. Rabkin CS4
  9. Liao LM4
  10. Sinha R4
  11. Johnson KC5
  12. Hu J6
  13. Zhang ZF7
  14. Palli D8
  15. Ferraroni M3, 9
  16. Negri E3, 10
  17. Turati F3
  18. Yu GP11
  19. Lunet N12, 13, 14
  20. Morais S12, 13, 14
  21. Lopezcarrillo L15
  22. Tsugane S16, 17
  23. Hidaka A18
  24. Malekzadeh R19
  25. Zaridze D20
  26. Maximovitch D20
  27. Vioque J21, 22
  28. Gonzalezpalacios S21, 22
  29. Ward MH23, 24
  30. Aragones N22, 25
  31. Castanovinyals G22, 26, 27, 28
  32. Curado MP29
  33. Diasneto E29
  34. Hamada GS30
  35. Hernandezramirez RU31
  36. Pakseresht M19, 32, 33
  37. Pourfarzi F34
  38. Mu L35
  39. Lagiou A36
  40. Lagiou P37, 38
  41. Lopezcervantes M39
  42. Dolci A40
  43. Boccia S41, 42
  44. Pastorino R41
  45. Boffetta P10, 43
  46. Davanzo B1
  47. La Vecchia C3
Show Affiliations
Authors Affiliations
  1. 1. Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri, 2, Milano, 20156, Italy
  2. 2. Italian Institute for Planetary Health (IIPH), Milan, Italy
  3. 3. Branch of Medical Statistics, Biometry, and Epidemiology “G.A. Maccacaro”, Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy
  4. 4. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States
  5. 5. School of Epidemiology and Public Health, Department of Medicine, University of Ottawa, Ottawa, Canada
  6. 6. Harbin Medical University, Harbin, China
  7. 7. Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA, United States
  8. 8. Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy
  9. 9. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
  10. 10. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
  11. 11. Medical Informatics Center, Peking University, Peking, China
  12. 12. EPIUnit – Instituto de Saude Publica da Universidade do Porto, Porto, Portugal
  13. 13. Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Porto, Portugal
  14. 14. Departamento de Ciencias da Saude Publica e Forenses e Educacao Medica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
  15. 15. Mexico National Institute of Public Health, Morelos, Mexico
  16. 16. Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan
  17. 17. International University of Health and Welfare Graduate School of Public Health, Tokyo, Japan
  18. 18. Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan
  19. 19. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  20. 20. Department of Clinical Epidemiology, N.N. Blokhin National Medical Research Center for Oncology, Moscow, Russian Federation
  21. 21. Instituto de Investigacion Sanitaria y Biomedica de Alicante, Universidad Miguel Hernandez (ISABIAL-UMH), Alicante, Spain
  22. 22. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
  23. 23. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States
  24. 24. Cancer Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain
  25. 25. Cancer Surveillance and Registry Unit, Public Health Division, Department of Health of Madrid, Madrid, Spain
  26. 26. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
  27. 27. Barcelona Institute for Global Health—ISGlobal, Barcelona, Spain
  28. 28. Universitat Pompeu Fabra (UPF), Barcelona, Spain
  29. 29. Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, Sao Paulo, Brazil
  30. 30. Nikkei Disease Prevention Center, Sao Paulo, Brazil
  31. 31. Department of Biostatistics, Yale School of Public Health, Yale School of Medicine, New Haven, CT, United States
  32. 32. Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada
  33. 33. Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom
  34. 34. Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  35. 35. Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United States
  36. 36. Department of Public and Community Health, School of Public Health, University of West Attica, Athens, Greece
  37. 37. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
  38. 38. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  39. 39. Facultad de Medicina, UNAM, Coyoacan, 04510, Mexico
  40. 40. Research and Development Department, Bolton Food SpA, Milan, Italy
  41. 41. Section of Hygiene, University Department of Life Sciences and Public Health, Universita Cattolica del Sacro Cuore, Roma, Italy
  42. 42. Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
  43. 43. Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, United States

Source: Scientific Reports Published:2025


Abstract

Gastric cancer is among the most common cancer and cause of cancer death. We conducted a meta-analysis of 25 case–control studies from the Stomach cancer Pooling Project to assess the association between fish or canned fish consumption and the risk of gastric cancer. 10,431 cases and 24,903 controls were available. We found no association between fish consumption and risk of gastric cancer (pooled odds ratios (OR) = 0.99; 95% confidence interval (CI) 0.86–1.13, for at least one serving/week vs none). Geographical differences were found: in Asia an increased intake of fish was associated with a lower stomach cancer risk. In the sensitivity analyses, fish consumption was associated to a lower risk of gastric cancer in models adjusted for family history of gastric cancer (OR = 0.80, 95% CI 0.72–0.89) and Helicobacter Pylori infection (OR = 0.72, 95% CI 0.60–0.88), but not for body mass index or energy intake. Seven studies collected information on canned fish (4525 cases and 8073 controls). No association was found for canned fish (OR = 0.96, 95% CI 0.82–1.13). In conclusion, our results provide evidence that fish and canned fish intake are not associated with gastric cancer risk, although geographical differences have been highlighted, with a lower risk of gastric cancer in Asia. © The Author(s) 2025.
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