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Sciatic Nerve Regeneration by Transplantation of Menstrual Blood-Derived Stem Cells Publisher Pubmed



Farzamfar S1 ; Naserinosar M2 ; Ghanavatinejad A3 ; Vaez A2 ; Zarnani AH4, 5 ; Salehi M6
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 1417755469, Iran
  3. 3. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, 141556447, Iran
  4. 4. Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, 117719615, Iran
  5. 5. Immunology Research Center, Iran University of Medical Sciences, Tehran, 1449614535, Iran
  6. 6. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, 3613773955, Iran

Source: Molecular Biology Reports Published:2017


Abstract

This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via a neural guidance conduit, for peripheral nerve regeneration. The synthesized poly (e-caprolactone)/Gelatin conduit, filled with collagen type I and seeded with 3 × 104 MenSCs, was implanted into a rat’s 10 mm sciatic nerve defect. The results of hot plate latency, sciatic functional index and weight-loss percentage of wet gastrocnemius muscle demonstrated that the MenSC transplantation had comparable nerve regeneration outcome to autograft, as the gold standard of nerve bridging. The transplantation of MenSCs via a synthetic conduit could ameliorate the functional recovery of sciatic nerve-injured rats which make them a potential candidate for cell therapy of peripheral nervous system disorders. © 2017, Springer Science+Business Media B.V.
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