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Interaction Between 3-Snp Genetic Risk Score and Dietary Fats Intake on Inflammatory Markers Among Overweight and Obese Women Publisher



Fateh ST1 ; Shiraseb F2 ; Hajinasab MM3 ; Noori S4 ; Clark CCT5 ; Mirzaei K2
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Science (TUMS), Tehran University of Medical Sciences (TUMS), P.O. Box: 14155-6117, Tehran, Iran
  3. 3. Department of Nutrition, Electronic Health and Statistics Surveillance Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  5. 5. Centre for Intelligent Healthcare, Coventry University, Coventry, CV1 5FB, United Kingdom

Source: Journal of Diabetes and Metabolic Disorders Published:2025


Abstract

Objectives: This study, for the first time, sought to investigate whether the interaction between the GRS consists of three SNPs (CAV-1, CRY-1, MC4R) and fat intake is associated with inflammatory markers among Iranian overweight and obese women. Methods: This cross-sectional study was conducted with 246 overweight and obese women, aged 18–48 years. Three SNPs, including CAV-1 rs3807992, CRY-1 rs2287161, and MC4R rs17782313, were genotyped using PCR-RFLP to calculate the genetic risk score (GRS) for each participant. Dietary fat intake was measured using a validated semi-quantitative food frequency questionnaire (FFQ). C-reactive protein (CRP), interleukin-1β (IL-1β), transforming growth factor-β (TGF-β), monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and Galectin-3 (Gal-3) were assessed as the primary outcomes of the study. Results: After controlling for confounding variables, a significant interaction between high total fat intake and high GRS, compared to the reference group, was found for TGF-β level (P-value: 0.028). A significant positive interaction between high GRS and high intakes of SFA intake (P-value: 0.013). A significant interaction between high GRS and high intakes of MUFA, compared to the reference group, was found for ghrelin level (P-value: 0.040) and MCP-1 level (P-value: 0.075). There was a significant interaction between high GRS and intakes of DHA, compared to the reference group, for Gal-3 level (P-value: 0.013) MCP-1 level (P-value: 0.020). Conclusions: Consuming different types of fats can influence the interaction between GRS and inflammatory markers, suggesting further research is needed to fully understand this relationship. © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2025.
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