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Vitamin D Levels in Multiple Sclerosis Patients: Association With Tgf-Β2, Tgf-Βri, and Tgf-Βrii Expression Publisher Pubmed



Shirvanifarsani Z1 ; Behmanesh M1 ; Mohammadi SM1 ; Moghadasi AN2
Authors
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Authors Affiliations
  1. 1. Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  2. 2. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Life Sciences Published:2015


Abstract

Aim: A variety of evidence suggests that vitamin D can prevent the development of multiple sclerosis (MS). TGF-β pathway genes also play important roles in MS. Here, we aim to study whether vitamin D affects TGF-β pathway gene expression and Expanded Disability Status Scale (EDSS) scores in MS patients. Main methods: A randomized clinical trial was conducted on 31 relapsing-remitting (RR) MS patients. Using realtime RT-PCR, we tested the levels of TGF-β2, TGF-βRI and TGF-βRII mRNAs in the RRMS patients before and after 8 weeks of supplementation with vitamin D. Key findings: Expression of TGF-β2 mRNA increased 2.84-fold, while TGF-βRI and TGF-βRII mRNA levels did not change after vitamin D treatment. In addition, these results revealed no correlation between the normalized expression of TGF-β2, TGF-βRI, or TGF-βRII and EDSS scores. Significance: Here, we demonstrate new evidence for the complex role of vitamin D in the pathogenesis, activity and progression of MS through the TGF-β signaling pathway. © 2015 Elsevier Inc. All rights reserved.
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