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Ginger’S Antiapoptotic and Antioxidant Effects on Ovaries of Cyclophosphamide-Therapied Rats Publisher Pubmed



Shahidi M1 ; Abazari O1 ; Dayati P2 ; Haghiralsadat BF3 ; Oroojalian F4 ; Reza JZ1 ; Naghib SM5, 6
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
  2. 2. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
  3. 3. Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  4. 4. Department of Advanced Technologies, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  5. 5. Nanotechnology Department, School of Advanced Technologies, Iran University of Science and Technology, Tehran, Iran
  6. 6. Biomaterials and Tissue Engineering Department, Breast Cancer Research Center, Motamed Cancer Institute, IUST, ACECR, Tehran, Iran

Source: Current Pharmaceutical Design Published:2023


Abstract

Background: In the recent decade, there has been increasing interest in preventing ovarian toxicity after chemotherapy exposure. It has been documented that ginger (Zingiber officinale) might normalize the hormonal balance and control the menstrual cycle. Objective: This study has analyzed whether ginger extract protects against cyclophosphamide (CP)-induced ovarian failure in rats. Methods: Rats were distributed into four groups consisting of vehicle, CP, ginger, and CP + ginger. At the end of the treatment, all rats were killed under anesthesia to obtain ovarian tissues and blood samples for histologi-cal, molecular, and biochemical experiments. Results: Our results indicated that ginger improves CP-caused histological changes in ovarian tissues and sig-nificantly restores serum hormonal abnormalities. Ginger also showed unique antioxidant, anti-inflammatory, and antiapoptotic properties in the ovarian tissues of CP-induced rats. Further, our findings indicated that ginger might activate the Nrf2 and SIRT and inhibit the PI3K/AKT pathway in the ovaries of CP-treated rats. In conclusion, ginger was found to protect against CP-caused ovarian toxicity in rats. Conclusion: The protective impacts of ginger may mediate, at least partly, by alleviating the oxidant state, inhibiting pro-inflammatory conditions, and exhibiting antiapoptotic activities. © 2023 Bentham Science Publishers.
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