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Synthesis, Molecular Docking, and Biological Evaluation of Nitroimidazole Derivatives As Potent Urease Inhibitors Publisher



Talebi M1 ; Hamidian E1 ; Niasarinaslaji F1 ; Rahmani S1 ; Hosseini FS1 ; Boumi S1 ; Montazer MN1 ; Asadi M1 ; Amanlou M1, 2
Authors
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Authors Affiliations
  1. 1. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Medicinal Chemistry Research Published:2021


Abstract

The objective of this study was to design new nitroimidazole-based derivatives as strong urease inhibitors for the treatment of H. pylori infections. New series of nitroimidazole derivatives, 4a–k, were synthesized by using TBTU as the catalyst and assayed as Jack bean urease inhibitors. The facile synthetic approach was employed for the preparation of targeted molecular designs in good to excellent yields, ranged from 65 to 92%. Accordingly, all the synthesized compounds, 4a–k (IC50 = 1.43–7.72 μM), were more potent than the standard urease inhibitors, thiourea, and hydroxyurea. Among the derivatives, 4d had the most urease inhibitor activity (IC50 = 1.43 μM), over 15-fold more potent than thiourea and 70-fold than hydroxyurea. True to form, the result of molecular docking studies was in good congruence with those obtained from in vitro tests. [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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