Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]

Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo] Publisher

Bozorgi M¹ ; Najafi Z² ; Omidpanah S³ ; Sadri A⁴ ; Narimani Z⁴ ; Moghadam FH⁵ ; Edraki N⁶ ; Akbarzadeh T^{1, 4} ; Saeedi M^{1, 3}

Show Affiliations

1. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
3. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
6. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas Published:2021

Abstract

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder. Sever cognitive and memory impairments, huge increase in the prevalence of the disease, and lacking definite cure have absorbed worldwide efforts to develop therapeutic approaches. Since many drugs have failed in the clinical trials due to multifactorial nature of AD, symptomatic treatments are still in the center attention and now, nootropic medicinal plants have been found as versatile ameliorators to reverse memory disorders. In this work, anti-Alzheimer’s activity of aqueous extract of areca nuts (Areca catechu L.) was investigated via in vitro and in vivo studies. It depicted good amyloid β (Aβ) aggregation inhibitory activity, 82% at 100 μg/mL. In addition, it inhibited beta-secretase 1 (BACE1) with IC50 value of 19.03 μg/mL. Evaluation of neuroprotectivity of the aqueous extract of the plant against H2O2-induced cell death in PC12 neurons revealed 84.5% protection at 1 μg/mL. It should be noted that according to our results obtained from Morris Water Maze (MWM) test, the extract reversed scopolamine-induced memory deficit in rats at concentrations of 1.5 and 3 mg/kg. © 2021, MS-Editions. All rights reserved.

Related Docs

View other Related Docs

1. Cinnamomum Verum J. Presl. Bark Essential Oil: In Vitro Investigation of Anti-Cholinesterase, Anti-Bace1, and Neuroprotective Activity, BMC Complementary Medicine and Therapies (2022)

2. Phytochemical Investigation and Anticholinesterase Activity of Ethyl Acetate Fraction of Myristica Fragrans Houtt. Seeds, Natural Product Research (2020)

3. Investigation of Polysaccharide Extracts From Iranian and French Strains of Agaricus Subrufescens Against Enzymes Involved in Alzheimer’S Disease; [Investigacion De Extractos De Polisacaridos De Cepas Iranies Y Francesas De Agaricus Subrufescens Contra Enzimas Relevantes Para La Enfermedad De Alzheimer], Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas (2019)

4. In Vitro Anti-Hsv1 Activity of Aqueous Extract of Areca Catechu L., Iranian Journal of Microbiology (2024)

5. Design, Synthesis, Biological Evaluation, and Docking Study of Novel Dual-Acting Thiazole-Pyridiniums Inhibiting Acetylcholinesterase and Β-Amyloid Aggregation for Alzheimer's Disease, Bioorganic Chemistry (2020)

6. Phytochemical Investigation and Biological Activity of Doronicum Pardalianches L. Roots Against Alzheimer’S Disease, Natural Product Research (2023)

7. Phytochemical Analysis and Evaluation of Biological Activity of Lawsonia Inermis Seeds Related to Alzheimer's Disease, Evidence-based Complementary and Alternative Medicine (2021)

8. Beneficial Effect of Brassica Nigra Fixed Oil on the Changes in Memory Caused by Β-Amyloid in an Animal Model, Pharmaceutical Sciences (2020)

Experts (# of related papers)

View all Related Experts

Mina Saeedi (11)

Tahmineh Akbarzadeh (10)

Style	Citing Format
MLA	Bozorgi M, et al.. "Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, vol. 20, no. 4, 2021, pp. 406-415.
APA	Bozorgi M, Najafi Z, Omidpanah S, Sadri A, Narimani Z, Moghadam FH, Edraki N, Akbarzadeh T, Saeedi M (2021). Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 20(4), 406-415.
Chicago	Bozorgi M, Najafi Z, Omidpanah S, Sadri A, Narimani Z, Moghadam FH, Edraki N, Akbarzadeh T, Saeedi M. "Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 20, no. 4 (2021): 406-415.
Harvard	Bozorgi M et al. (2021) 'Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]', Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 20(4), pp. 406-415.
Vancouver	Bozorgi M, Najafi Z, Omidpanah S, Sadri A, Narimani Z, Moghadam FH, et al.. Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 2021;20(4):406-415.
BibTex	@article{ author = {Bozorgi M and Najafi Z and Omidpanah S and Sadri A and Narimani Z and Moghadam FH and Edraki N and Akbarzadeh T and Saeedi M}, title = {Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]}, journal = {Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas}, volume = {20}, number = {4}, pages = {406-415}, year = {2021} }
RIS	TY - JOUR AU - Bozorgi M AU - Najafi Z AU - Omidpanah S AU - Sadri A AU - Narimani Z AU - Moghadam FH AU - Edraki N AU - Akbarzadeh T AU - Saeedi M TI - Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo] JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas VL - 20 IS - 4 SP - 406 EP - 415 PY - 2021 ER -

Style

Citing Format

MLA

Bozorgi M, et al.. "Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, vol. 20, no. 4, 2021, pp. 406-415.

APA

Bozorgi M, Najafi Z, Omidpanah S, Sadri A, Narimani Z, Moghadam FH, Edraki N, Akbarzadeh T, Saeedi M (2021). Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 20(4), 406-415.

Chicago

Bozorgi M, Najafi Z, Omidpanah S, Sadri A, Narimani Z, Moghadam FH, Edraki N, Akbarzadeh T, Saeedi M. "Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]." Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 20, no. 4 (2021): 406-415.

Harvard

Bozorgi M et al. (2021) 'Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]', Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 20(4), pp. 406-415.

Vancouver

Bozorgi M, Najafi Z, Omidpanah S, Sadri A, Narimani Z, Moghadam FH, et al.. Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]. Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas. 2021;20(4):406-415.

BibTex

@article{ author = {Bozorgi M and Najafi Z and Omidpanah S and Sadri A and Narimani Z and Moghadam FH and Edraki N and Akbarzadeh T and Saeedi M}, title = {Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]}, journal = {Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas}, volume = {20}, number = {4}, pages = {406-415}, year = {2021} }

RIS

TY - JOUR
AU - Bozorgi M
AU - Najafi Z
AU - Omidpanah S
AU - Sadri A
AU - Narimani Z
AU - Moghadam FH
AU - Edraki N
AU - Akbarzadeh T
AU - Saeedi M
TI - Investigation of Anti-Alzheimer’S Activity of Aqueous Extract of Areca Nuts (Areca Catechu L.): In Vitro and in Vivo Studies; [Investigacion De La Actividad Anti-Alzheimer Del Extracto Acuoso De Nueces De Areca (Areca Catechu L.): Estudios in Vitro E in Vivo]
JO - Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
VL - 20
IS - 4
SP - 406
EP - 415
PY - 2021
ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract