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Seroprevalence of Toxocariasis Among Hypereosinophilic Children: A Single Center Study, Tehran, Iran Publisher



Sharifdini M1 ; Zarean M2 ; Sadredinamin M3 ; Zarebavani M4 ; Sharifiyazdi S5 ; Nikmanesh B4, 6
Authors
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Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  2. 2. Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Medical Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Zoonoses Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Pediatric Infectious Diseases Published:2023


Abstract

Background: Toxocariasis is a parasitic disease causing hypereosinophilia. This study aimed to investigate the serological prevalence of toxocariasis among hypereosinophilic children in Children’s Medical Center, Tehran, Iran, as well as to explore its relationship with epidemiological variables and some blood indices. Methods: This descriptive cross-sectional study was performed in 2020 on children referred to referral children hospital for routine tests. A total of 282 children diagnosed with hypereosinophilia were selected and included in the study, and then, their serum was collected. After obtaining informed consent from their parents, the parents were asked to fill out a questionnaire. The serological ELISA test was used to assess the anti-Toxocara IgG antibody. Data were analyzed using SPSS software 18. Results: Out of 282 hypereosinophilic children, 17 (6%) had serological results positive for anti-Toxocara antibody. The mean age of children with toxocariasis was higher than that of children without toxocariasis (P = 0.312). Furthermore, ESR and CRP variables were significantly higher in infected children than those in non-infected children (P < 0.05). Conclusions: The results of the present study confirmed the relationship between toxocariasis and hypereosinophilia. Since the symptoms of toxocariasis are non-specific and may go undiagnosed, it was found necessary to examine toxocariasis in cases of hy-pereosinophilic individuals. © 2022, Author(s).
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