Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Main Issues in Penetrating Keratoplasty Publisher



Jl Alio Jorge L ; S Niazi SANA ; F Doroodgar FARIDEH ; Jl Aliodel Barrio Jorge L ; H Hashemi HASSAN ; Ma Javadi Mohammad ALI
Authors

Source: Taiwan Journal of Ophthalmology Published:2024


Abstract

This review explores contemporary challenges in penetrating keratoplasty (PK), focusing on technical intricacies, technological advancements, and strategies for preventing graft rejection. A systematic literature search from January 2018 to July 2023 was conducted across PubMed, Cochrane, Web of Science, Scopus, and EMBASE. The inclusion criteria comprised studies on PK and its comparison with other corneal pathologies, with emphasis on keratoconus (KC). Two independent reviewers screened studies, extracting relevant data. The review covers PK evolution, highlighting infra-red femtosecond lasers' impact on graft shapes, minimizing astigmatism, and enhancing wound healing. Graft rejection, a primary complication, is examined, detailing risk factors and preventive measures. Preoperative considerations, diagnostic techniques for rejection, and PK in KC are discussed. Postoperative care's significance, including intraocular pressure monitoring and steroid administration, is emphasized. The paper concludes with a comprehensive approach to prevent graft rejection, involving topical and systemic medications. An outlook on evolving monoclonal antibody research is presented. As the field progresses, personalized approaches and ongoing therapeutic exploration are expected to refine strategies, enhancing PK outcomes. © 2024 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Main Issues in Deep Anterior Lamellar Keratoplasty: A Systematic Narrative Review, Taiwan Journal of Ophthalmology (2024)
2. Corneal Transplantation in Keratoconus, Keratoconus: Optical and Surgical Management (2024)
3. Evaluation of Corneal Biomechanics After Excimer Laser Corneal Refractive Surgery in High Myopic Patients Using Dynamic Scheimpflug Technology, Eye and Contact Lens (2017)
Experts (# of related papers)
View all Related Experts
Mehrdad Mohammadpour (4)
Masoud Khorrami-Nejad (4)
Other Related Docs
4. Smile After Dalk to Reduce Residual Refraction: Two-Year Results, International Ophthalmology (2022)
5. Corneal Collagen Cross-Linking in the Treatment of Progressive Keratoconus: A Randomized Controlled Contralateral Eye Study, Middle East African Journal of Ophthalmology (2015)
6. Femtosecond Laser-Assisted Keratopigmentation Outcomes for Pure Cosmetic Purposes, American Journal of Ophthalmology Case Reports (2025)
7. Updates on Managements for Keratoconus, Journal of Current Ophthalmology (2018)
8. Short-Term Comparison of Accelerated and Standard Methods of Corneal Collagen Crosslinking, Journal of Cataract and Refractive Surgery (2015)
9. Sutureless Femtosecond Laser-Assisted Anterior Lamellar Keratoplasty Using a Bioengineered Cornea As a Viable Alternative to Human Donor Transplantation for Superficial Corneal Opacities, Cornea (2020)
10. Visual, Keratometric and Corneal Biomechanical Changes After Intacs Sk Implantation for Moderate to Severe Keratoconus, Journal of Ophthalmic and Vision Research (2016)
11. Efficacy of Myoring Implantation in the Treatment of Keratoconus; [Myoring 植入术治疗圆锥角膜的疗效观察], International Eye Science (2024)
12. Management of Lenticule Detachment and Epithelial Downgrowth After Descemet Stripping Automated Endothelial Keratoplasty: A Novel Technique and Brief Literature Review, BMC Ophthalmology (2022)
13. Visual and Refractive Outcomes and Tomographic Changes After Femtosecond Laser-Assisted Intrastromal Corneal Ring Segment Implantation in Patients With Keratoconus, Journal of Ophthalmic and Vision Research (2018)
14. Application of Polycaprolactone Nanofibers As Patch Graft in Ophthalmology, Indian Journal of Ophthalmology (2018)
15. In Vivo Confocal Microscopic Evaluation of Corneal Changes in Acute Endothelial Rejection, Journal of Current Ophthalmology (2021)
16. Cxl Under Special Conditions: Pediatrics, Pack Cxl, Pixl, and Conductive Keratoplasty, Keratoconus: Optical and Surgical Management (2024)
17. Long-Term Results of an Accelerated Corneal Cross-Linking Protocol (18 Mw/Cm2) for the Treatment of Progressive Keratoconus, American Journal of Ophthalmology (2015)
18. Corneal Cross-Linking Combined With Lasik, Lasek, Prk, Ptk, and Smile Refractive Surgeries, Keratoconus: Optical and Surgical Management (2024)
19. Keratoconus: Optical and Surgical Management, Keratoconus: Optical and Surgical Management (2024)
20. Safety of Grafting Acellular Human Corneal Lenticule Seeded With Wharton's Jelly-Derived Mesenchymal Stem Cells in an Experimental Animal Model, Experimental Eye Research (2021)