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Netosis in Ischemic/Reperfusion Injuries: An Organ-Based Review Publisher Pubmed



Hashemi P1 ; Nourivaskeh M2, 3, 4 ; Alizadeh L5 ; Baghbanzadeh A4 ; Badalzadeh R6 ; Askari E7 ; Baradaran B4
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Tropical and Communicable Diseases Research Centre, Iranshahr University of Medical Sciences, Iranshahr, Iran
  3. 3. Network of Immunity in Infection, Malignancy and Autoimmunity, Universal Scientific Education and Research Network, Tehran, Iran
  4. 4. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Liver and Gastrointestinal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Life Sciences Published:2022


Abstract

Neutrophil extracellular trap (NETosis), the web-like structures induced by neutrophil death, is an important inflammatory mechanism of the immune system leading to reactive oxygen species production/coagulopathy, endothelial dysfunction, atherosclerosis, and ischemia. NETosis exerts its role through different mechanisms such as triggering Toll-like receptors, inflammatory cytokines, platelet aggregation, neutrophil activation/infiltration, and vascular impairment. NETosis plays a key role in the prognosis of coronary artery disease, ischemic injury of kidney, lung, gastrointestinal tract and skeletal muscles. In this review, we explored the molecular mechanisms involved in NETosis, and ischemic/reperfusion injuries in body organs. © 2021
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