Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Hematological Parameters Alterations in Different Waves of Covid-19 Pandemic: A Cross-Sectional Study Publisher Pubmed



Charostad J1, 2 ; Rukerd MRZ3 ; Shahrokhi A4 ; Aghda FA2 ; Ghelmani Y5, 6 ; Pourzand P7 ; Pourshaikhali S8 ; Dabiri S9 ; Dehghani A10 ; Astani A1, 2 ; Nakhaie M3 ; Kakavand E11
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Microbiology, Faculty of Medicine, Shahid-Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  6. 6. Clinical Research Development Center of Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  7. 7. Department of Emergency Medicine, Kerman University of Medical Sciences, Kerman, Iran
  8. 8. Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran
  9. 9. Department of Pathology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  10. 10. Department of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  11. 11. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: PLoS ONE Published:2023


Abstract

Background The occurrence of variations in routine hematological parameters is closely associated with disease progression, the development of severe illness, and the mortality rate among COVID-19 patients. This study aimed to investigate hematological parameters in COVID-19 hospitalized patients from the 1st to the 5th waves of the current pandemic. Methods This cross-sectional study included a total of 1501 hospitalized patients with laboratory-confirmed COVID-19 based on WHO criteria, who were admitted to Shahid Sadoughi Hospital (SSH) in Yazd, Iran, from February 2020 to September 2021. Throughout, we encountered five COVID-19 surge waves. In each wave, we randomly selected approximately 300 patients and categorized them based on infection severity during their hospitalization, including partial recovery, full recovery, and death. Finally, hematological parameters were compared based on age, gender, pandemic waves, and outcomes using the Mann-Whitney U and Kruskal-Wallis tests. Results The mean age of patients (n = 1501) was 61.1±21.88, with 816 (54.3%) of them being men. The highest mortality in this study was related to the third wave of COVID-19 with 21.3%. There was a significant difference in all of the hematological parameters, except PDW, PLT, and RDW-CV, among pandemic waves of COVID-19 in our population. The highest rise in the levels of MCV and RDW-CV occurred in the 1st wave, in the 2nd wave for lymphocyte count, MCHC, PLT count, and RDW-SD, in the 3rd wave for WBC, RBC, neutrophil count, MCH, and PDW, and in the 4th wave for Hb, Hct, and ESR (p < 0.01). The median level of Hct, Hb, RBC, and ESR parameters were significantly higher, while the mean level of lymphocyte and were lower in men than in women (p < 0.001). Also, the mean neutrophil in deceased patients significantly was higher than in those with full recovered or partial recovery (p < 0.001). Conclusion The findings of our study unveiled notable variations in hematological parameters across different pandemic waves, gender, and clinical outcomes. These findings indicate that the behavior of different strains of the COVID-19 may differ across various stages of the pandemic. © 2023 Charostad et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Other Related Docs
11. Health Care Policies and Covid-19 Prevalence: Is There Any Association?, International Journal of Health Services (2022)
14. Covid-19 and Its Global Economic Impact, Advances in Experimental Medicine and Biology (2021)
21. The Epidemiologic Aspects of Covid-19 Outbreak: Spreading Beyond Expectations, Advances in Experimental Medicine and Biology (2021)
22. A Systematic Review of Pregnant Women With Covid-19 and Their Neonates, Archives of Gynecology and Obstetrics (2021)
23. Health and Art (Heart): Integrating Science and Art to Fight Covid-19, Advances in Experimental Medicine and Biology (2021)
28. Interdisciplinary Approaches to Covid-19, Advances in Experimental Medicine and Biology (2021)
29. Microfluidic Devices for Detection of Rna Viruses, Reviews in Medical Virology (2021)
30. Serological Tests for Covid-19: Potential Opportunities, Cell Biology International (2021)
31. Coronavirus: Pure Infectious Disease or Genetic Predisposition, Advances in Experimental Medicine and Biology (2021)
33. Neurologic Manifestations of Covid-19, Advances in Experimental Medicine and Biology (2021)
34. The Role of Lovastatin in the Attenuation of Covid-19, International Immunopharmacology (2021)
35. Geriatrics and Covid-19, Advances in Experimental Medicine and Biology (2021)
40. Nutrition and Immunity in Covid-19, Advances in Experimental Medicine and Biology (2021)
42. Covid-19 in Patients With Cancer, Advances in Experimental Medicine and Biology (2021)
44. Clinical Manifestations of Covid-19, Advances in Experimental Medicine and Biology (2021)