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Evaluation of the Presence of Epstein-Barr Virus (Ebv) in Iranian Patients With Thyroid Papillary Carcinoma Publisher Pubmed



Homayouni M1, 2 ; Mohammad Arabzadeh SA2, 6 ; Nili F3, 7, 8 ; Razi F4 ; Amoli MM5
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Virology, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular—Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Kerman University of Medical Sciences, End of 22 Bahman Blv, Kerman, Iran
  7. 7. Imam Khomeini Hospital, End of Keshavarz Blv, Tehran, Iran
  8. 8. Shariati Hospital, North Kargar St., Tehran, Iran

Source: Pathology Research and Practice Published:2017


Abstract

Background and purpose Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. EBV is one of the most important viruses related to different types of malignancies. This study investigated the relationship between EBV and papillary thyroid carcinoma. Material and methods In this study the presence of Epstein-Barr Nuclear Antigen 1 (EBNA1) gene in papillary thyroid carcinoma tissues were examined by nested-PCR method. Paraffin-embedded tissues (N = 41) blocks of thyroid cancer were used. DNA was extracted from all samples and then samples were evaluated for the presence of EBV gene. Results In 41 samples, EBNA1 was detected in 65.8% of patients with papillary thyroid carcinoma which was significantly higher in younger ages. Conclusion The significant presence of EBV genome in papillary thyroid carcinoma suggests that this virus may play a role in this cancer especially in younger ages. As a result, monitoring of patients with EBV latent infection for PTC can be very important. © 2017 Elsevier GmbH
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