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Epstein-Barr Virus and Risk of Breast Cancer: A Systematic Review and Meta-Analysis Publisher Pubmed



Farahmand M1 ; Monavari SH2 ; Shoja Z3 ; Ghaffari H2 ; Tavakoli M4 ; Tavakoli A2
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Virology Department, Pasteur Institute of Iran, Tehran, Iran
  4. 4. Faculty of Electrical and Computer Engineering, Malek-Ashtar University of Technology, Tehran, Iran

Source: Future Oncology Published:2019


Abstract

Despite the numerous publications regarding the role of Epstein-Barr virus (EBV) in breast cancer development, the topic has still remained controversial. The aim of the meta-analysis was to estimate the overall prevalence of EBV in the breast cancer population, and to investigate the association between EBV and breast cancer risk. The overall prevalence of EBV was calculated 26.37% (95% CI: 22-31%) from the 44 included studies. Meta-analysis of 30 case-control studies showed that the pooled association between EBV and risk of breast cancer is odds ratio 4.74 (95% CI: 2.92-7.69; Z = 6.30; p < 0.0001). Our analyses indicate a strong statistical relationship between EBV infection and risk of breast cancer, suggesting a potential role of EBV infection in the development of breast cancer. © 2019 Future Medicine Ltd.
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