Alpha- Glucosidase Inhibition Analysis and in Silico Studies of New Tetrahydroquinazolin-4(1H)-One Derivatives

Alpha- Glucosidase Inhibition Analysis and in Silico Studies of New Tetrahydroquinazolin-4(1H)-One Derivatives Publisher

Tajmirriahi A¹ ; Hosein Sayahi M² ; Nazari Montazer M³ ; Shemirani F¹ ; Mirzazadeh R⁴

Show Affiliations

1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
2. Department of Chemistry, Payame Noor University, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Biochemistry Department, Pasteur Institute of Iran, Tehran, Iran

Source: Results in Chemistry Published:2024

Abstract

In this work, a new series 3-phenylamine-2,3-dihydroquinazolin-4(1H)-one-phenoxy-acetamid derivatives 7a-m was designed using by hybridization of effective pharmacophores of the potent anti-α-glucosidase agents. These compounds were synthesized by the simple and efficient chemical reactions and evaluated for their inhibitory activity against α-glucosidase. Our results demonstrated that all derivatives 7a-m were more active than positive control. Particularly, compound 7h as the most potent compound was 63.2-folds more potent than positive control. Kinetic study revealed that compound 7 h was a competitive α-glucosidase inhibitor. Furthermore, docking and dynamics of compound 7h were studied. The latter in silico studied demonstrated that compound 7h with a favorable binding energy occupied the active site of α-glucosidase. © 2024

2. Imidazo[1,2-C]Quinazolines As a Novel and Potent Scaffold of Α-Glucosidase Inhibitors: Design, Synthesis, Biological Evaluations, and in Silico Studies, Scientific Reports (2023)

3. 1-Phenyl-Β-Carboline-3-Carboxamide-1,2,3-Triazole-N-Phenylacetamide Hybrids As New Α-Glucosidase Inhibitors, Scientific Reports (2025)

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Style	Citing Format
MLA	Tajmirriahi A, et al.. "Alpha- Glucosidase Inhibition Analysis and in Silico Studies of New Tetrahydroquinazolin-4(1H)-One Derivatives." Results in Chemistry, vol. 9, no. , 2024, pp. -.
APA	Tajmirriahi A, Hosein Sayahi M, Nazari Montazer M, Shemirani F, Mirzazadeh R (2024). Alpha- Glucosidase Inhibition Analysis and in Silico Studies of New Tetrahydroquinazolin-4(1H)-One Derivatives. Results in Chemistry, 9(), -.
Chicago	Tajmirriahi A, Hosein Sayahi M, Nazari Montazer M, Shemirani F, Mirzazadeh R. "Alpha- Glucosidase Inhibition Analysis and in Silico Studies of New Tetrahydroquinazolin-4(1H)-One Derivatives." Results in Chemistry 9, no. (2024): -.
Harvard	Tajmirriahi A et al. (2024) 'Alpha- Glucosidase Inhibition Analysis and in Silico Studies of New Tetrahydroquinazolin-4(1H)-One Derivatives', Results in Chemistry, 9(), pp. -.
Vancouver	Tajmirriahi A, Hosein Sayahi M, Nazari Montazer M, Shemirani F, Mirzazadeh R. Alpha- Glucosidase Inhibition Analysis and in Silico Studies of New Tetrahydroquinazolin-4(1H)-One Derivatives. Results in Chemistry. 2024;9():-.
BibTex	@article{ author = {Tajmirriahi A and Hosein Sayahi M and Nazari Montazer M and Shemirani F and Mirzazadeh R}, title = {Alpha- Glucosidase Inhibition Analysis and in Silico Studies of New Tetrahydroquinazolin-4(1H)-One Derivatives}, journal = {Results in Chemistry}, volume = {9}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Tajmirriahi A AU - Hosein Sayahi M AU - Nazari Montazer M AU - Shemirani F AU - Mirzazadeh R TI - Alpha- Glucosidase Inhibition Analysis and in Silico Studies of New Tetrahydroquinazolin-4(1H)-One Derivatives JO - Results in Chemistry VL - 9 IS - SP - EP - PY - 2024 ER -

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Abstract