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Phenytoin Accelerates Tendon Healing in a Rat Model of Achilles Tendon Rupture Publisher Pubmed



Hajipour B1, 2, 3 ; Navali AM4 ; Ali Mohammad Zadeh Taher S5 ; Mousavi G6 ; Gahvechi Akbari M7 ; Maleki Miyandoab T1, 2, 3 ; Roshangar L8 ; Mohammadi Saleh B6 ; Asvadi Kermani T9 ; Moutab Laleh F6 ; Ghabili M10
Authors
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Authors Affiliations
  1. 1. Department of Surgery, Urmia University of Medical Sciences, Urmia, Iran
  2. 2. Army University of Medical Sciences, Tehran, Iran
  3. 3. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  4. 4. Department of Orthopedics, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Orthopedics, Army University of Medical Sciences, Tehran, Iran
  6. 6. Department of Clinical Sciences, Faculty of Veterinary Sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran
  7. 7. Department of Physical Medicine and Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Histology, Tabriz University of Medical Sciences, Tabriz, Iran
  9. 9. Department of Surgery, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Bratislava Medical Journal Published:2016


Abstract

INTRODUCTION: Tendons are vulnerable to various types of acute or chronic injures. Different methods have been investigated to achieve better healing. Phenytoin is a drug which could stimulate fibroblasts to produce collagen. This experimental study was performed to assess the effect of phenytoin on tendon healing in a rat model of tendon rupture. METHODS: Thirty healthy rats were divided into 3 groups, 1) Sham group; 2) Tendon rupture; 3) Tendon rupture+phenytoin (100 mg/kg intraperitoneally) for 21 days. On 21st day after tendon injury, the rats were anesthetized and tendon tissue was sampled for studying by light and electron microscopy. RESULTS: Qualitative and quantitative microscopic comparisons of the repair tissues of both groups were made on the 21st day. The results obtained from light and electron microscopy studies showed that tendon tissue healing was significantly better in phenytoin group compared to the control group (p < 0.05). CONCLUSIONS: Systemic administration of phenytoin may have a positive effect on tendon healing by increasing fibroblast quantity, fibrillar collagen synthesis, vascularity, and suppressing inflammation.
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