Montmorillonite-Famotidine/Chitosan Bio-Nanocomposite Hydrogels As a Mucoadhesive/Gastroretentive Drug Delivery System Publisher



Farhadnejad H^{1, 2} ; Mortazavi SA¹ ; Jamshidfar S³ ; Rakhshani A⁴ ; Motasadizadeh H⁴ ; Fatahi Y^{4, 5, 6} ; Mahdieh A⁴ ; Darbasizadeh B¹ Show Affiliations
Source: Iranian Journal of Pharmaceutical Research Published:2022

Abstract

The main purpose of the present study was to fabricate mucoadhesive bio-nanocomposite hydrogels to prolong the drug retention time in the stomach. In these bio-nanocomposite hydrogels, chitosan (CH) was used as a bioadhesive matrix, montmorillonite (MMT) was applied to modulate the release rate, and tripolyphosphate (TPP) was the cross-linking agent. The test samples were analyzed via different methods such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). Drug incorporation efficacy and mucoadhesive strength of these nanocom-posite hydrogel beads were studied. Swelling and in vitro drug release behaviors of these bio-nanocomposite hydrogels were eval-uated in simulated gastric fluid (SGF; pH 1.2). The optimized MMT-famotidine (FMT)/CH bio-nanocomposite hydrogels displayed a controllable and sustainable drug release profile with suitable mucoadhesion and prolonged retention time in the stomach. Thus, the results demonstrated that the fabricated mucoadhesive bio-nanocomposite hydrogels could remarkably increase the therapeutic efficacy and bioavailability of FMT by the oral route. © 2022, Author(s).