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Molecular Evidence Reveals Thyrotropin Intervention Enhances the Risk of Developing Radioiodine-Refractory Differentiated Thyroid Carcinoma Publisher



Samimi H1 ; Haghpanah V1, 2
Authors
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center (EMRC), Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Cancer Cell International Published:2022


Abstract

Radioiodine (RAI) is the mainstay of treatment for differentiated thyroid carcinoma (DTC) following total thyroidectomy. Nevertheless, about 5% of patients with DTC are RAI-refractory (RAI-R). Understanding the molecular mechanisms associated with DTC during progression towards RAI-R DTC, including thyroid-stimulating hormone levels, may help to explain the pathophysiology of challenging RAI-R DTC clinical cases. Graphical Abstract: [Figure not available: see fulltext.] © 2022, The Author(s).