Tehran University of Medical Sciences

Science Communicator Platform

Share By
The Effect of Month of Birth on Multiple Sclerosis: A Sase-Control Study in Northeast Iran Pubmed



Sarmadi M1 ; Nezhad MR3 ; Hasanluyi FA5 ; Najafi F6 ; Tamaddon A7 ; Rahimi S1
Authors

Source: Acta neurologica Taiwanica Published:2022


Abstract

BACKGROUND: Multiple sclerosis (MS) is an autoimmune and multi-factorial (e.g. environmental, genetic) disease. We conducted a case-control study of month and season of birth (MOB and SOB) and multiple sclerosis (MS) risk in the east of Iran. METHODS: The MS patients registered in Mashhad and Torbat Heydariyeh MS Society until 20 March 2018 was compared with the MOB and SOB in the healthy population during 1988 to 2018. Case group was matched for age, sex and place of residence with the control group. Differences in the distributions of MOB and SOB between the patients and the control groups were assessed using the chi-square test. RESULTS: There were 2,160 MS patients in case group and 2,245 in control group. There was a significant relationship between MOB ans SOB with the risk of MS (P less than 0.05). Analysis showed a significant (p less than 0.01) peak in the MOB during Mar-Apr (OR is equal to 1.60), May-Jun (OR is equal to 1.30) and Aug-Sep (OR is equal to 2.42). CONCLUSION: The findings show a relationship between MOB and SOB as risk factor for MS in Northeast Iran. Further studies are needed to confirm this result. Keyword: Multiple sclerosis, Month of Birth, seasonality, case-control, Iran.
Related Docs
View other Related Docs
1. Comparing Epidemiology and Baseline Characteristic of Multiple Sclerosis and Neuromyelitis Optica: A Case-Control Study, Multiple Sclerosis and Related Disorders (2017)
2. Epidemiological Parameters of Multiple Sclerosis in Chaharmahal and Bakhtiari Province, Iran, Current Journal of Neurology (2023)
3. Registry-Based Incidence of Multiple Sclerosis in Southwestern Iran, 2001-2014, Bangladesh Medical Research Council Bulletin (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Sahraian (13)
Sharareh Eskandarieh (7)
Other Related Docs
4. Multiple Sclerosis Associated Risk Factors: A Case-Control Study, Iranian Journal of Public Health (2015)
5. Multiple Sclerosis Projection in Tehran, Iran Using Bayesian Structural Time Series, BMC Neurology (2021)
6. Parental Ethnicity Associated With Risk for Multiple Sclerosis: A Population-Based Incident Case–Control Study in Iran, Multiple Sclerosis and Related Disorders (2018)
7. Age and Sex Adjusted Prevalence and Annual Incidence of Multiple Sclerosis in East-Azerbaijan, Iran, Multiple Sclerosis and Related Disorders (2021)
8. Prevalence of Multiple Sclerosis and Its Clinical and Demographic Characteristics in Kurdish Populations in Western Iran (2020), Multiple Sclerosis and Related Disorders (2022)
9. Concomitant Multiple Sclerosis and Another Autoimmune Disease: Does the Clinical Course Change?, Clinical Neurology and Neurosurgery (2016)
10. Temporal Trends of Incidence and Prevalence of Multiple Sclerosis in Razavi Khorasan Province, Northeast Iran, Neurological Sciences (2022)
11. Prescription Trends of Disease-Modifying Treatments for Multiple Sclerosis in Iran Over the Past 30 Years, Multiple Sclerosis and Related Disorders (2022)
12. The Trend of Incidence, Prevalence, and Daly of Multiple Sclerosis in the Middle East and Northern Africa Region Compared to Global, West Europe And, Iran's Corresponding Values During 1990–2017: Retrieved From Global Burden of Diseases Data, Multiple Sclerosis and Related Disorders (2021)
13. Prevalence of Multiple Sclerosis in Iranian Emigrants: Review of the Evidence, Neurological Sciences (2016)
14. Clinical Features of Late-Onset Multiple Sclerosis: A Systematic Review and Meta-Analysis, Multiple Sclerosis and Related Disorders (2021)
15. Multiple Sclerosis and Human Leukocyte Antigen Genotypes: Focus on the Middle East and North Africa Region, Multiple Sclerosis Journal - Experimental# Translational and Clinical (2020)
16. Evidence of an Increased Prevalence of Multiple Sclerosis: A Population-Based Study of Tehran Registry During 1999-2018, BMC Neurology (2020)
17. Consanguineous Marriage Among Familial Multiple Sclerosis Subjects: A National Registry-Based Study, Heliyon (2024)
18. Stress-Full Life Events and Multiple Sclerosis: A Population-Based Incident Case-Control Study, Multiple Sclerosis and Related Disorders (2018)
19. Association of Il2ra and Multiple Sclerosis Risk: A Case Control, Systematic Review, and Meta-Analysis Study, Journal of the Neurological Sciences (2025)
20. The Epidemiologic Trend of Multiple Sclerosis in Razavi Khorasan Province, Iran in Fifteen-Year Period, Multiple Sclerosis and Related Disorders (2025)