Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! By
Effect of Ondansetron on Postoperative Pain and Vomiting After Acute Appendicitis Surgery: A Placebo-Controlled Double-Blinded Randomized Clinical Trial Publisher Pubmed



M Khoori MOEIN ; P Mirghaderi PEYMAN ; A Azarboo ALIREZA ; F Jamil FOROUGH ; N Eshraghi NASIM ; A Abdullahzadehbaghaei ALIREZA
Authors

Source: Pain Research and Management Published:2024


Abstract

Background: Common postoperative complications following surgery, particularly acute appendicitis surgery, include postoperative pain and vomiting, which can cause discomfort and delay recovery time. Methods: A randomized double-blinded placebo-controlled clinical trial was conducted with 80 cases of acute appendicitis of American Society of Anesthesiologists (ASA) physical status I or II and aged 18-60 y/o scheduled for appendectomy under general anesthesia. Patients were randomly divided into two equal groups: group A received 4 mg of ondansetron IV (2 ml) and group B received 2 ml of normal slain IV (placebo). Pain according to VAS, nausea and vomiting according to clinical symptoms, shivering and sedation according to the Bedside Shivering Assessment Scale (BSAS), and the Ramsay Sedation Scale (RSS) at 2, 6, 12, and 24 hours after surgery were evaluated and compared between the groups. Results: There was a significant decline in the severity of pain only at 2 hours after surgery between the ondansetron and control groups (5.3 ± 1.0 vs. 6.0 ± 1.0; p=0.01), not showing a difference between the groups at 6, 12, and 24 hours after appendectomy. Postoperative nausea and vomiting at 2 (5% vs. 25%; p=0.03) and 6 (7.5% vs. 27.5%; p=0.04) hours after appendectomy in the ondansetron group. At different times, the ondansetron and control groups did not differ in terms of pethidine consumption or sedation. Conclusions: In conclusion, our study found that ondansetron was effective in reducing postoperative vomiting after acute appendicitis surgery. However, it did not show a clinically significant effect on postoperative pain. This trial is registered with IRCT20230722058883N1. This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
Related Docs
View other Related Docs
1. Effect of Paracetamol Versus Ibuprofen in Adenotonsillectomy, Iranian Journal of Otorhinolaryngology (2021)
2. Prophylactic Administration of Diphenhydramine/Acetaminophen and Ondansetron Reduced Postoperative Nausea and Vomiting and Pain Following Laparoscopic Sleeve Gastrectomy: A Randomized Controlled Trial, Obesity Surgery (2021)
3. Comparison of Post‐Operative Nausea and Vomiting With Intravenous Versus Inhalational Anesthesia in Laparotomic Abdominal Surgery: A Randomized Clinical Trial; [Comparacao Entre Anestesia Intravenosa E Inalatoria Na Nausea E Vomito Pos‐Operatorios Em Laparotomia: Estudo Clinico Randomizado], Brazilian Journal of Anesthesiology (2020)
Experts (# of related papers)
View all Related Experts
Pejman Pourfakhr (2)
Mojgan Rahimi (2)
Other Related Docs
4. The Effect of Preoperative Pentoxifylline on Postoperative Pain and Development of Secondary Hyperalgesia in Patients Undergoing Laparoscopic Appendectomy: A Randomized, Double-Blind, Placebo-Controlled Trial Study, Pain Practice (2021)
5. The Efficacy of Addition of Dexmedetomidine to Intrathecal Bupivacaine in Lower Abdominal Surgery Under Spinal Anesthesia, Caspian Journal of Internal Medicine (2019)
6. The Effect of Premedication With Oral Acetaminophen on the Prevention of Localized Pain Resulting From Intravenous Propofol Injection: A Randomized Double Blind Placebo Clinical Trial, Archives of Anesthesiology and Critical Care (2024)
7. Comparison Between Two Methods of Patient-Controlled Analgesia Through Intravenous and Thoracic Epidural to Control Pain and Complications After Surgery in Esophageal Cancer Patients: A Randomized Controlled Trial, Acta Medica Iranica (2023)
8. Prevalence of Postoperative Nausea and Vomiting in Orthopedic Patients in Imam Khomeini Hospital Complex During 2018-2019: A Cross-Sectional Study, Archives of Anesthesiology and Critical Care (2023)
9. A Comparative Study of the Effect of Oral Dextromethorphan and Placebo on the Pain After Vitrectomy Surgery: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial, Iranian Red Crescent Medical Journal (2018)
10. Spinal Anesthesia and Spinal Anesthesia With Subdiaphragmatic Lidocaine in Shoulder Pain Reduction for Gynecological Laparoscopic Surgery: A Randomized Clinical Trial, Pain Research and Management (2017)
11. Fentanyl-Midazolam Vs. Midazolam-Ketamine Regarding Patient Sedation Analgesia for Emergency Orthopedic Procedures, Bangladesh Journal of Pharmacology (2017)
12. Incidence of Postoperative Vomiting and Laryngospasm in Pediatric Anesthesia Using Two Methods: Controlled Ventilation and Spontaneous Respiration, Shiraz E Medical Journal (2015)
13. Effect of Intravenous Acetaminophen on Postoperative Pain in Vitrectomy: A Randomized, Double-Blind, Clinical Trial, Anesthesiology and Pain Medicine (2017)
14. The Comparison of Infusion of Two Different Sedation Regimens With Propofol and Ketamine Combination During Plastic and Reconstructive Surgery, Aesthetic Plastic Surgery (2015)
15. Effectiveness of Intravenous Lidocaine Versus Intravenous Morphine in Reducing Acute Extremity Trauma-Induced Pain: A Triple-Blind Randomized Clinical Trial, Koomesh (2020)
16. Effect of Preoperative Duloxetine on Opioid Consumption in Women Undergoing Abdominal Hysterectomy: A Randomized, Double-Blinded, Placebo-Controlled Trial, Anesthesiology and Pain Medicine (2020)
17. Three-Agent Preemptive Analgesia, Pregabalin-Acetaminophen-Naproxen, in Laparotomy for Cancer: A Randomized Clinical Trial, Anesthesiology and Pain Medicine (2017)
18. Intraoperative Administration of Methadone Reduced Postoperative Pain and Opioid Consumption Following Ca-Daveric Renal Transplantation: A Randomized Controlled Trial, Frontiers in Emergency Medicine (2023)
19. Ultrasound-Guided Fascia Iliaca Compartment Block in Orthopedic Fractures: Bupivacaine 0.2% or 0.3%?, Medical Journal of the Islamic Republic of Iran (2016)
20. Efficacy of Laparoscopic Transversus Abdominis Plane Block on Postoperative Pain Management and Surgery Side Effects in Laparoscopic Bariatric Surgeries, Langenbeck's Archives of Surgery (2022)