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Sars-Cov-2-Related Mis-C: A Key to the Viral and Genetic Causes of Kawasaki Disease? Publisher Pubmed



Sanchoshimizu V1, 2 ; Brodin P3 ; Cobat A4, 5, 6, 83 ; Biggs CM7, 8 ; Toubiana J9, 10 ; Lucas CL11 ; Henrickson SE12, 13 ; Belot A14, 15 ; Tangye SG16, 17 ; Milner JD18 ; Levin M1, 2 ; Abel L4, 5, 6, 83 ; Bogunovic D19 ; Casanova JL4, 5, 6, 20, 83 Show All Authors
Authors
  1. Sanchoshimizu V1, 2
  2. Brodin P3
  3. Cobat A4, 5, 6, 83
  4. Biggs CM7, 8
  5. Toubiana J9, 10
  6. Lucas CL11
  7. Henrickson SE12, 13
  8. Belot A14, 15
  9. Tangye SG16, 17
  10. Milner JD18
  11. Levin M1, 2
  12. Abel L4, 5, 6, 83
  13. Bogunovic D19
  14. Casanova JL4, 5, 6, 20, 83
  15. Zhang SY4, 5, 6, 83
  16. Haddad E21
  17. Beland K21
  18. Pujol A22, 23, 24
  19. Schluter A22
  20. Planasserra L22
  21. Aguileraalbesa S25
  22. Valenciaramos J26
  23. Rodriguezpalmero A27
  24. Gut M28
  25. Riviere JG29
  26. Colobran R30
  27. Solerpalacin P29
  28. Rodriguezgallego C31, 32
  29. De Diego RP33, 34
  30. Flores C35, 36, 37, 38
  31. Alsina L39
  32. Blazquezgamero D40
  33. Jordan I41
  34. Keles S42
  35. Emiroglu M43
  36. Akcan OM42
  37. Alkan G44
  38. Aytekin SE42
  39. Gul Y42
  40. Tuter Oz SK44
  41. Bozdemir SE45
  42. Bayhan GI46
  43. Yuksek SK47
  44. Parlakay AO46
  45. Gulhan B47
  46. Yahsi A47
  47. Kilic AO42
  48. Karbuz A48
  49. Erdeniz EH49
  50. Ozkan EA49
  51. Orbak Z50
  52. Aydemir S51
  53. Celik JB44
  54. Kandemir B42
  55. Aytekin G52
  56. Kapakli H53
  57. Yarar V53
  58. Yosunkaya A42
  59. Vatansev H42
  60. Aytekin C54
  61. Torun SH55
  62. Nepesov S56
  63. Coskuner T57
  64. Sozeri B57
  65. Demirkol YK58
  66. Kasapcopur O59
  67. Yildiz M59
  68. Sevketoglu E60
  69. Hatipoglu N61
  70. Ozcelik T62
  71. Yesilbas O63
  72. Gayretli Aydin ZG64
  73. Sediva A65
  74. Klocperk A65
  75. Bloomfield M65, 66
  76. Meyts I67
  77. Delafontaine S67
  78. Haerynck F68
  79. Hoste L68
  80. Shahrooei M69
  81. Marque L70
  82. Neves JF71, 72
  83. Novelli G73
  84. Novelli A74
  85. Aiuti A75
  86. Casari G75
  87. Bousfiha AA76
  88. Almuhsen SZ77
  89. Sobh A78
  90. Gagro A79, 80
  91. Bajolle F81
  92. Bonnet D81
  93. Lebon P82
  94. Lei W4, 83
  95. Lee D4, 83
  96. Seeleuthner Y84, 85
  97. Zhang P4, 83
  98. Maglorius M84, 85
  99. Philippot Q84, 85
  100. Pelham S4, 83
  101. Bastard P84, 85
  102. Zhang Q4, 83
  103. Jouanguy E84, 85
  104. Puel A84, 85
  105. Herberg J86
  106. Kuijpers TW87, 88
  107. Bellos E86
  108. Kaforou M86
  109. Menikou S86
  110. Panhammarstrom Q89
  111. Hammarstrom L90
  112. Abolhassani H89
  113. Bryceson Y91
  114. Condinoneto A92
  115. Prando C93
  116. Bando SY94
  117. Cavalcanti A95
  118. Fellay J96, 97
  119. Blanchardhohner G98
  120. Mansouri D99
  121. Mahmoudi S100
  122. Boyarchuk O101
  123. Volokha A102
  124. Bondarenko A103
  125. Stepanovskiy Y103
  126. Mogensen T104
  127. Van De Beek D105
  128. Andreakos E106
  129. Papadaki M106
  130. Tayoun AA107, 108
  131. Halwani R109
  132. Almulla F110
  133. Franco JL111
  134. Lau YL112
  135. Kwan M113
  136. Imai K114
  137. Okada S115
  138. Bolze A116
  139. Butte MJ117
  140. Hsieh E118
  141. Drolet BA119
  142. Arkin L119
  143. Itan Y120
  144. Maniatis T121
  145. Arditi M122
  146. Cooper M123
  147. Schmitt E123
  148. Chakravorty S124
  149. Anderson MS125
  150. Su HC126
  151. Notarangelo LD126
Show Affiliations
Authors Affiliations
  1. 1. Department of Paediatric Infectious Diseases and Virology, Imperial College London, London, United Kingdom
  2. 2. Centre for Paediatrics and Child Health, Faculty of Medicine, Imperial College London, London, United Kingdom
  3. 3. Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
  4. 4. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, United States
  5. 5. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sante et de la Recherche Medicale, Necker Hospital for Sick Children, Paris, France
  6. 6. University of Paris, Imagine Institute, Paris, France
  7. 7. Department of Pediatrics, University of British Columbia, Vancouver, Canada
  8. 8. British Columbia Children's Hospital Research Institute, Vancouver, Canada
  9. 9. Department of General Pediatrics and Pediatric Infectious Diseases, Necker Hospital for Sick Children, Assistance Publique - Hopitaux de Paris, University of Paris, Paris, France
  10. 10. Pasteur Institute, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France
  11. 11. Department of Immunobiology, Yale University, School of Medicine, New Haven, CT, United States
  12. 12. Division of Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, United States
  13. 13. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States
  14. 14. Centre International de Recherche en Infectiologie, University of Lyon, Institut National de la Sante et de la Recherche Medicale, U1111, Universite Claude Bernard, Lyon 1, Le Centre National de la Recherche Scientifique, UMR5308, Lyon, France
  15. 15. National Reference Center for Rheumatic, Autoimmune and Systemic Diseases in Children (RAISE), Pediatric Nephrology, Rheumatology, Dermatology Unit, Hopital Femme Mere Enfant, Hospices Civils de Lyon, Lyon, France
  16. 16. Garvan Institute of Medical Research, Darlinghurst, Australia
  17. 17. St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales Sydney, Sydney, Australia
  18. 18. Department of Pediatrics, Columbia University, Irving Medical Center, New York, NY, United States
  19. 19. Center for Inborn Errors of Immunity, Precision Immunology Institute, Mindich Child Health and Development Institute, Department of Microbiology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States
  20. 20. Howard Hughes Medical Institute, New York, NY, United States
  21. 21. Department of Pediatrics, Department of Microbiology, Immunology and Infectious Diseases, University of Montreal, CHU Sainte-Justine, Montreal, QC, Canada
  22. 22. Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran I Reynals, Barcelona, Catalonia, Spain
  23. 23. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Catalonia, Spain
  24. 24. CIBERER U759, ISCiii, Madrid, Spain
  25. 25. Navarra Health Service Hospital, Pamplona, Spain
  26. 26. University Hospital of Burgos, Burgos, Spain
  27. 27. University Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
  28. 28. CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Carrer Baldiri i Reixac 4, Barcelona, 08028, Spain
  29. 29. Pediatric Infectious Diseases and Immunodeficiencies Unit, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain
  30. 30. Immunology Division, Genetics Department, Vall d'Hebron Research Institute, Vall d'Hebron Barcelona Hospital Campus, Universitat Autonoma de Barcelona, Barcelona, Catalonia, Spain
  31. 31. Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain
  32. 32. Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain
  33. 33. Laboratory of Immunogenetics of Human Diseases, Innate Immunity Group, IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain
  34. 34. Interdepartmental Group of Immunodeficiencies, Madrid, Spain
  35. 35. Research Unit, Hospital Universitario Nuestra Senora de la Candelaria, Santa Cruz de Tenerife, Spain
  36. 36. Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), Granadilla de Abona, Spain
  37. 37. CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
  38. 38. Instituto de Tecnologias Biomedicas (ITB), Universidad de La Laguna, Santa Cruz de Tenerife, Spain
  39. 39. Unit of Clinical Immunology and Primary Immunodeficiencies, Hospital Sant Joan de Deu, Barcelona, Spain
  40. 40. Pediatric Infectious Diseases Unit, Instituto de Investigacion 12 de Octubre imas12, Hospital Universitario 12 de Octubre, Madrid, Spain
  41. 41. Pediatric Intensive Care Unit, Hospital Sant Joan de Deu, Kids Corona Platfform, Barcelona, Spain
  42. 42. Necmettin Erbakan University, Konya, Turkey
  43. 43. Division of Pediatric Infectious Diseases, Department of Pediatrics, Selcuk University, Faculty of Medicine, Konya, Turkey
  44. 44. Selcuk University, Konya, Turkey
  45. 45. Bursa City Hospital, Bursa, Turkey
  46. 46. Yildirim Beyazit University, Ankara City Hospital, Ankara, Turkey
  47. 47. Ankara City Hospital, Ankara, Turkey
  48. 48. Prof.Dr.Cemil Tascioglu City Hospital, Istanbul, Turkey
  49. 49. Ondokuz Mayis University, Samsun, Turkey
  50. 50. Ataturk University, Erzurum, Turkey
  51. 51. Dr Ali Kemal Belviranli State Hospital, Konya, Turkey
  52. 52. Konya City Hospital, Konya, Turkey
  53. 53. Balikesir City Hospital, Balikesir, Turkey
  54. 54. Department of Pediatric Immunology, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey
  55. 55. Department of Pediatric Infectious Disease, Faculty of Medicine, Istanbul University, Istanbul, Turkey
  56. 56. Pediatric allergy and immunology Unit, Istanbul Medipol University, Istanbul, Turkey
  57. 57. Division of Pediatric Rheumatology, Umraniye Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
  58. 58. Department of Pediatric Genetics, Health Sciences University, Umraniye Education and Research Hospital, Istanbul, Turkey
  59. 59. Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Turkey
  60. 60. Pediatric Intensive Care Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
  61. 61. Pediatric Infectious Diseases Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
  62. 62. Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
  63. 63. Department of Pediatrics, Division of Pediatric Critical Care Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
  64. 64. Department of Pediatrics, Division of Pediatric Infectious Disease, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
  65. 65. Department of Immunology, 2nd Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic
  66. 66. Department of Pediatrics, First Faculty of Medicine, Charles University and Thomayer's Hospital, Prague, Czech Republic
  67. 67. Department of Pediatrics, University Hospitals Leuven, Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium
  68. 68. Primary Immunodeficiency Research Lab, Center for Primary Immunodeficiency Ghent, Ghent University Hospital, Ghent, Belgium
  69. 69. Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
  70. 70. Immunodeficiencies snd infectous diseases Unit, Pediatric Department, Centro Materno-Infantil do Norte, Centro Hospitalar Universitario do Porto, Porto, Portugal
  71. 71. Primary Immunodeficiencies Unit, Hospital Dona Estefania, CHULC, EPE, Portugal
  72. 72. CEDOC, Center for Chronic Diseases, Portugal
  73. 73. Department of Biomedicine and Prevention, Tor Vergata University of Rome, Italy
  74. 74. UOC Genetica Medica, Ospedale Pediatrico, Bambino Gesu, Rome, Italy
  75. 75. Pediatric Immunohematology, San Raffaele Hospital, Salute San Raffaele University, Italy
  76. 76. Clinical Immunology Unit, Casablanca Children's Hospital, Ibn Rochd Medical School, King Hassan II University, Casablanca, Morocco
  77. 77. Prince Naif Center for Immunology Research, King Saud University, Riyadh, Saudi Arabia
  78. 78. Department of Pediatrics, Mansoura University, Children's Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt
  79. 79. Department of Paediatrics, University of Zagreb, School of Medicine, Children's Hospital Zagreb, Zagreb, Croatia
  80. 80. Josip Juraj Strossmayer University of Osijek, Medical Faculty Osijek, Osijek, Croatia
  81. 81. Department of Pediatric Cardiology, Necker Hospital for Sick Children, AP-HP, University of Paris, Paris, France
  82. 82. Medical School, University of Paris, Paris, France
  83. 83. St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, United States
  84. 84. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U.1163, Necker Hospital for Sick Children, France
  85. 85. Paris Descartes University, Imagine Institute, France
  86. 86. Dept of Paediatric Infectious Diseases and Virology, Imperial College London, London, United Kingdom
  87. 87. Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Center, University of Amsterdam, Netherlands
  88. 88. Emma Children's Hospital, Department of Pediatric Immunology, Rheumatology and Infectious Disease, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
  89. 89. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, SE14183, Sweden
  90. 90. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, SE14186, Sweden
  91. 91. Center for Hematology and Regenerative Medicine, Depatment of Medicine, Karolinska Institute, Stockholm, Sweden
  92. 92. Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo SP, Brazil
  93. 93. Faculdades Pequeno Principe, Instituto de Pesquisa Pele Pequeno Principe, Curitiba, Brazil
  94. 94. Laboratory of Pediatric Genomics, Faculty of Medicine, University of Sao Paulo, Sao Paulo SP, Brazil
  95. 95. Department of Pediatrics, Clinical Hospital of Federal University of Pemambuco, Recife, Brazil
  96. 96. School of Life Sciences, EPFL, Lausanne, Switzerland
  97. 97. Precision Medicine Unit, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland
  98. 98. Unit of Immunology and Vaccinology, Division of General Pediatrics, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals, University of Geneva, Geneva, Switzerland
  99. 99. Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  100. 100. Pediatric infectious disease research center, Tehran University of Medical Sciences, Tehran, Iran
  101. 101. Department of Children's Diseases and Pediatric Surgery, I.Horbachevsky Ternopil National Medical University, Ukraine
  102. 102. Department of Pediatric Infectious Diseases and Pediatric Immunology, Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
  103. 103. Pediatric Infectious Disease and Pediatric Immunology Department, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine
  104. 104. Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark
  105. 105. Amsterdam University Medical Center UMC, Amsterdam, Netherlands
  106. 106. Department of Immunobiology, Center for Clinical, Experimental Surgery and Clinical Research, Biomedical Research Foundation, The Academy of Athens, Greece
  107. 107. Al Jalila Genomics Center, Al Jalila Children's Specialty Hospital, Dubai, United Arab Emirates
  108. 108. Genetics Department, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates
  109. 109. College of Medicine, University of Shajah, Shajah, United Arab Emirates
  110. 110. Dasman Diabetes Institute, Center of Genomic Medicine, Kuwait University, Kuwait
  111. 111. Department of Microbiology and Parasitology, School of Medicine, University of Antioquia, Medellin, Colombia
  112. 112. Department of Paediatrics and Adolescent Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong
  113. 113. Princess Margaret Hospital, Hong Kong
  114. 114. Department of Community Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University, Japan
  115. 115. Department of Pediatrics, Hiroshima University, Graduate School of Biomedical and Health Sciences, Japan
  116. 116. Helix, San Mateo, CA, United States
  117. 117. Department of Pediatrics, Division of Immunology, Allergy, and Rheumatology University of California, Los Angeles, CA, United States
  118. 118. Department of Pediatrics, Section of Allergy and Immunology, Department of Immunology and Microbiology, University of Colorado, Anschutz Medical Campus, Children's Hospital Colorado, CO, United States
  119. 119. University of Wisconsin, School of Medicine, Madison, WI, United States
  120. 120. Icahn School of Medicine at Mount Sinai, New York, NY, United States
  121. 121. New York Genomic Center, New York, NY, United States
  122. 122. Cedars Sinai Medical Center, UCLA School of Medicine, University of California, Los Angeles, CA, United States
  123. 123. Department of Pediatrics, Division of Rheumatology/Immunology, Washington University in St. Louis, St. Louis, MO, United States
  124. 124. Emory University Department of Pediatrics, Emory + Children's Center forFOR Neurosciences Research (CCNR), Atlanta, GA, United States
  125. 125. Diabetes Center, University of California, San Francisco, CA, United States
  126. 126. Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States

Source: Journal of Experimental Medicine Published:2021


Abstract

Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses. © 2021 Sancho-Shimizu et al.
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