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Circular Rnas in Tuberculosis: From Mechanism of Action to Potential Diagnostic Biomarker Publisher Pubmed



Kazemi S1 ; Mirzaei R2 ; Karampoor S3 ; Hosseinifard SR4 ; Ahmadyousefi Y5, 6 ; Soltanian AR7 ; Keramat F1 ; Saidijam M6 ; Alikhani MY1, 8
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Authors Affiliations
  1. 1. Infectious Disease Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Venom and Biotherapeutics Molecules Lab, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
  3. 3. Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  7. 7. Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Iran
  8. 8. Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Source: Microbial Pathogenesis Published:2023


Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), continues to be a major global health concern. Understanding the molecular intricacies of TB pathogenesis is crucial for developing effective diagnostic and therapeutic approaches. Circular RNAs (circRNAs), a class of single-stranded RNA molecules characterized by covalently closed loops, have recently emerged as potential diagnostic biomarkers in various diseases. CircRNAs have been demonstrated to modulate the host's immunological responses against TB, specifically by reducing monocyte apoptosis, augmenting autophagy, and facilitating macrophage polarization. This review comprehensively explores the roles and mechanisms of circRNAs in TB pathogenesis. We also discuss the growing body of evidence supporting their utility as promising diagnostic biomarkers for TB. By bridging the gap between fundamental circRNA biology and TB diagnostics, this review offers insights into the exciting potential of circRNAs in combatting this infectious disease. © 2023 Elsevier Ltd
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