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Role of the Liver Capsule As a Traditional Medicine Formulation in the Treatment of Non-Alcoholic Fatty Liver Disease in Rats Publisher



Albooyeh S1 ; Khadem E2 ; Jeivad F1, 3 ; Vaghefi AM1 ; Hassanzadeh G4 ; Aliasl F5 ; Gholami M1, 3 ; Delasoud S1 ; Sabzevari O1, 3
Authors
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Authors Affiliations
  1. 1. Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Toxicology and Poisoning Research Centre, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Traditional Persian Medicine, Qom University of Medical Sciences, Qom, Iran

Source: Pharmaceutical Chemistry Journal Published:2024


Abstract

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury all over the world. Its main characteristic is a fat accumulation in the liver, which is not due to alcohol abuse. This study was aimed at investigating the therapeutic and protective effect of a traditional, complementary product called the liver capsule on NAFLD. NAFLD was induced by a high-fat diet (HFD). Forty male Wistar rats were divided into eight groups; consisting of: standard control, HFD control, lifestyle modification, post-treatment, co-treatment, and treatment. The effectiveness of liver capsules was examined through assessment of liver enzymes, biochemical parameters, antioxidant levels, and lipid peroxidation.We also performed histological examination on liver tissues. Statistical analysis was performed, and p values less than 0.05 were considered significant. Treatment with l capsule lowered hepatic damage markers, serum glucose level, and serum lipid levels. Rats treated with liver capsule had enhanced antioxidant activity and reduced lipid peroxidation. The higher dose (10 mg/kg) presented lower levels in all the parameters mentioned. Longer duration of treatment in co-treatment groups caused an increase in oxidation activity. The liver capsule could not decrease biochemical markers to baseline in animals without lifestyle modification (p > 0.05). Accordingly, the liver capsule has both therapeutic and protective effects on NAFLD owing to multi-target mechanisms and can be a candidate for further assessments in clinical studies. Our traditional product showed a therapeutic effect, but it seems that lifestyle modification plays a key role in the therapeutic process for NAFLD. © Springer Science+Business Media, LLC, part of Springer Nature 2024.