Allele Frequency of Genetic Variations Related to the Ugt1a1 Gene-Drug Pair in a Group of Iranian Population Publisher



Sarhangi N¹ ; Fahimfar N^{2, 3} ; Rouhollah F¹ ; Sharifi F⁴ ; Bidkhori M⁵ ; Nikfar S⁶ ; Ostovar A^{2, 3} ; Nabipour I⁷ ; Patrinos GP^{8, 9, 10} ; Hasanzad M¹¹
Source: Journal of Diabetes and Metabolic Disorders Published:2024

Abstract

Objectives: The efficacy and safety of drug treatments vary widely due to genetic variations. Pharmacogenomics investigates the impact of genetic variations on patient drug response. This research investigates the frequency of UGT1A1 genetic variations in the Iranian population, comparing them with global data to provide insights into the pharmacogenomic approach in the Iranian population. Methods: The study was conducted using the data of the Bushehr Elderly Health (BEH) program, a population-based cohort study of the elderly population aged ≥ 60 years. Genotyping of three UGT1A1 variant alleles (UGT1A1*6, UGT1A1*27, and UGT1A1*80) was performed on a group of 2730 elderly Iranian participants with the Infinium Global Screening Array. Results: The genotyping analysis revealed significant differences compared to major global populations that were addressed in the gnomAD database. UGT1A1*80 was found at a high frequency (32.34%), and followed by UGT1A1*6 (0.76%) and UGT1A1*27 (0.018) at a low frequency in the Iranian group. Conclusions: The UGT1A1*80 was the more prevalent allele between investigated alleles in the present study which can be considered as an important allele for pharmacogenomic testing. © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024.