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Variation in the Mirna-433 Binding Site of Fgf20 Is a Risk Factor for Parkinson's Disease in Iranian Population Publisher Pubmed



Haghnejad L1 ; Emamalizadeh B1 ; Jamshidi J2 ; Bidoki AZ3 ; Ghaedi H1 ; Ahmadi E4 ; Abdollahi S5 ; Shahmohammadibeni N6 ; Taghavi S1 ; Fazeli A1 ; Motallebi M1 ; Zarneh AES1 ; Mohammadihosseinabad S7 ; Abbaszadegan MR8 Show All Authors
Authors
  1. Haghnejad L1
  2. Emamalizadeh B1
  3. Jamshidi J2
  4. Bidoki AZ3
  5. Ghaedi H1
  6. Ahmadi E4
  7. Abdollahi S5
  8. Shahmohammadibeni N6
  9. Taghavi S1
  10. Fazeli A1
  11. Motallebi M1
  12. Zarneh AES1
  13. Mohammadihosseinabad S7
  14. Abbaszadegan MR8
  15. Torkamandi S1
  16. Gavenaroudi MA5
  17. Pedram N9
  18. Shahidi GA10
  19. Tafakhori A11
  20. Darvish H1
  21. Movafagh A1
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
  5. 5. Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
  7. 7. Department of Genetics, School of Medicine, Unit of Medical Sciences, Islamic Azad University, Tehran, Iran
  8. 8. Division of Human Genetics, Immunology Research Center, Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  9. 9. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  10. 10. Movement Disorders Clinic, Hazrat Rassol Hospital, Iran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Neurology, School of Medicine, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of the Neurological Sciences Published:2015


Abstract

DNA variations in the fibroblast growth factor 20 gene have been reported to be associated with Parkinson's disease (PD). The rs12720208, a functional SNP located in the 3′UTR region of the gene, was reported as a risk factor for PD. A number of studies, which tried to replicate the result in different populations, failed to detect any associations. In this study, we genotyped rs2720208 SNP in 520 PD patients and 520 healthy controls both from Iran. Significant differences were found in allele and genotype frequencies between patients and controls (p < 0.0001 for both). Our results suggest that the rs12720208 polymorphism may be a risk factor for PD in Iranian population. © 2015 Elsevier B.V. All rights reserved.
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