Curcumin-Coated Gold Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity Via Regulating Apoptosis in a Mouse Model

Curcumin-Coated Gold Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity Via Regulating Apoptosis in a Mouse Model Publisher Pubmed

Sharifiaghdam Z^{1, 2} ; Dalouchi F² ; Sharifiaghdam M^{3, 4} ; Shaabani E^{3, 4} ; Ramezani F⁵ ; Nikbakht F² ; Azizi Y^{2, 5}

Show Affiliations

1. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
2. Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences (TUMS, Tehran, Iran
4. Laboratory of General Biochemistry & Physical Pharmacy, Ghent University, Ghent, Belgium
5. Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Clinical and Experimental Pharmacology and Physiology Published:2022

Abstract

Doxorubicin (DOX) is one of the most widely used chemotherapy agents; however, its nonselective effect causes cardiotoxicity. Curcumin (Cur), a well known dietary polyphenol, could exert a significant cardioprotective effect, but the biological application of this substance is limited by its chemical insolubility. To overcome this limitation, in this study, we synthesised gold nanoparticles based on Cur (Cur-AuNPs). Ultraviolet-visible (UV-Vis) absorbance spectroscopy and transmission electron microscopy (TEM) were performed for the characterisation of synthesised NPs, and Fourier transform infrared (FTIR) spectroscopy were applied to detect Cur on the surface of AuNPs. Its cytotoxicity effect on H9c2 cells was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The biological efficacy of Cur-AuNPs was assessed after acute cardiotoxicity induction in BALB/c mice with DOX injection. The serum biomarkers, myocardial histological changes, and cardiomyocyte apoptosis were then measured. The results revealed that the heart protection by Cur-AuNPs is more effective than Cur alone. Heart protective effect of Cur-AuNPs was evident both in the short-term (24 hours) and long-term (14 days) study. The results of Cur-AuNPs400 after 24 hours of toxicity induction displayed the reduction of the cardiac injury serum biomarkers (LDH, CK-MB, cTnI, ADT, and ALT) and apoptotic proteins (Bax and Caspase-3), as well as increase of Bcl-2 anti-apoptotic proteins without any sign of interfibrillar haemorrhage and intercellular spaces in the heart tissue microscopic images. Our long-term study signifies that Cur-AuNPs400 in DOX-intoxicated mice could successfully inhibit body and heart weight loss in comparison to DOX group. © 2021 John Wiley & Sons Australia, Ltd.

2. A Systematic Review of Nonclinical Studies on the Effect of Curcumin in Chemo-Therapy-Induced Cardiotoxicity, Current Pharmaceutical Design (2022)

3. Anthracycline-Induced Cardiomyopathy in Cancer Survivors: Management and Long-Term Implications, Advances in Experimental Medicine and Biology (2025)

Experts (# of related papers)

Babak Arjmand (1)

Mohammad Abdollahi (1)

Style	Citing Format
MLA	Sharifiaghdam Z, et al.. "Curcumin-Coated Gold Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity Via Regulating Apoptosis in a Mouse Model." Clinical and Experimental Pharmacology and Physiology, vol. 49, no. 1, 2022, pp. 70-83.
APA	Sharifiaghdam Z, Dalouchi F, Sharifiaghdam M, Shaabani E, Ramezani F, Nikbakht F, Azizi Y (2022). Curcumin-Coated Gold Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity Via Regulating Apoptosis in a Mouse Model. Clinical and Experimental Pharmacology and Physiology, 49(1), 70-83.
Chicago	Sharifiaghdam Z, Dalouchi F, Sharifiaghdam M, Shaabani E, Ramezani F, Nikbakht F, Azizi Y. "Curcumin-Coated Gold Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity Via Regulating Apoptosis in a Mouse Model." Clinical and Experimental Pharmacology and Physiology 49, no. 1 (2022): 70-83.
Harvard	Sharifiaghdam Z et al. (2022) 'Curcumin-Coated Gold Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity Via Regulating Apoptosis in a Mouse Model', Clinical and Experimental Pharmacology and Physiology, 49(1), pp. 70-83.
Vancouver	Sharifiaghdam Z, Dalouchi F, Sharifiaghdam M, Shaabani E, Ramezani F, Nikbakht F, et al.. Curcumin-Coated Gold Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity Via Regulating Apoptosis in a Mouse Model. Clinical and Experimental Pharmacology and Physiology. 2022;49(1):70-83.
BibTex	@article{ author = {Sharifiaghdam Z and Dalouchi F and Sharifiaghdam M and Shaabani E and Ramezani F and Nikbakht F and Azizi Y}, title = {Curcumin-Coated Gold Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity Via Regulating Apoptosis in a Mouse Model}, journal = {Clinical and Experimental Pharmacology and Physiology}, volume = {49}, number = {1}, pages = {70-83}, year = {2022} }
RIS	TY - JOUR AU - Sharifiaghdam Z AU - Dalouchi F AU - Sharifiaghdam M AU - Shaabani E AU - Ramezani F AU - Nikbakht F AU - Azizi Y TI - Curcumin-Coated Gold Nanoparticles Attenuate Doxorubicin-Induced Cardiotoxicity Via Regulating Apoptosis in a Mouse Model JO - Clinical and Experimental Pharmacology and Physiology VL - 49 IS - 1 SP - 70 EP - 83 PY - 2022 ER -

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