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Micrornas-Mediated Regulation Pathways in Rheumatic Diseases Publisher Pubmed



Assadiasl S1 ; Rajabinejad M2, 3 ; Soleimanifar N1 ; Makiyan F4 ; Azizi E5 ; Rezaiemanesh A6 ; Nicknam MH1
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Authors Affiliations
  1. 1. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Division of Nanobiotechnology, Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
  5. 5. Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  6. 6. Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Daneshgah Street, Shahid Shiroudi Boulevard, PO-Box: 6714869914, Bakhtaran, Iran

Source: Inflammopharmacology Published:2023


Abstract

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are two common rheumatic disorders marked by persistent inflammatory joint disease. Patients with RA have osteodestructive symptoms, but those with AS have osteoproliferative manifestations. Ligaments, joints, tendons, bones, and muscles are all affected by rheumatic disorders. In recent years, many epigenetic factors contributing to the pathogenesis of rheumatoid disorders have been studied. MicroRNAs (miRNAs) are small, non-coding RNA molecules implicated as potential therapeutic targets or biomarkers in rheumatic diseases. MiRNAs play a critical role in the modulation of bone homeostasis and joint remodeling by controlling fibroblast-like synoviocytes (FLSs), chondrocytes, and osteocytes. Several miRNAs have been shown to be dysregulated in rheumatic diseases, including miR-10a, 16, 17, 18a, 19, 20a, 21, 27a, 29a, 34a, 103a, 125b, 132, 137, 143, 145, 146a, 155, 192, 203, 221, 222, 301a, 346, and 548a.The major molecular pathways governed by miRNAs in these cells are Wnt, bone-morphogenic protein (BMP), nuclear factor (NF)-κB, receptor activator of NF-κB (RANK)—RANK ligand (RANKL), and macrophage colony-stimulating factor (M-CSF) receptor pathway. This review aimed to provide an overview of the most important signaling pathways controlled by miRNAs in rheumatic diseases. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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