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Effects of Drugs and Chemotherapeutic Agents on Dental Implant Osseointegration: A Narrative Review Publisher Pubmed



Mohammadi A1 ; Dehkordi NR2 ; Mahmoudi S3 ; Rafeie N4 ; Sabri H5 ; Valizadeh M6 ; Poorsoleiman T7 ; Jafari A1 ; Mokhtari A8 ; Khanjarani A8 ; Salimi Y9 ; Mokhtari M8 ; Deravi N10
Authors
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Authors Affiliations
  1. 1. Dental Materials Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  2. 2. Department of Periodontology, Faculty of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  3. 3. Department of Endodontics, School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
  4. 4. Dental Research Center, Dentistry Research Institute, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Research Center, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
  7. 7. Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran
  8. 8. Student Research Committee, Dental Faculty, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  9. 9. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  10. 10. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Current Reviews in Clinical and Experimental Pharmacology Published:2024


Abstract

Background: Dental implants have been one of the most popular treatments for rehabilitating individuals with single missing teeth or fully edentulous jaws since their introduction. As more implant patients are well-aged and take several medications due to various systemic conditions, clinicians should take into consideration the possible drug implications on bone remodeling and osseointegration. Objective: The present study aims to examine and review some desirable and unwelcomed implications of medicine on osseointegration. Methods: A broad search for proper relevant studies was conducted in four databases, including Web of Science, Pubmed, Scopus, and Google Scholar. Results: Some commonly prescribed medicines, such as nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, proton pump inhibitors (PPIs), selective serotonin reuptake inhibitors (SSRIs), anticoagulants, metformin, and chemotherapeutic agents, may jeopardize osseointegration. On the contrary, some therapeutic agents, such as anabolic, anti-catabolic, or dual anabolic agents may enhance osseointegration and increase the treatment’s success rate. Conclusion: Systemic medications that enhance osseointegration include mineralization promoters and bone resorption inhibitors. On the other hand, medications often given to the elderly with systemic problems might interfere with osseointegration, leading to implant failure. However, to validate the research, more human studies with a higher level of evidence are required. © 2024 Bentham Science Publishers.
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