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Injectable Hydrogel and Its Potential Therapy for Peri-Implantitis Publisher



F Feili FAHIMEH ; H Valadbeigi HASSAN ; B Negahdari BABAK ; S Khooshnod SAEED ; A Maleki ABBAS ; Mh Haddadi Mohammad HOSSEIN
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2025


Abstract

Peri-implantitis is a destructive inflammatory condition around dental implants, crucial in implantology due to its impact on implant failure, with prevalence ranging from 10 to 20% of implants. Injectable hydrogel has gained attention as a promising biomaterial for the prevention and treatment of peri-implantitis, offering a minimally invasive approach to infection control, inflammation modulation, and tissue regeneration. The use of bioactive agents such as antibiotics, growth factors, stem cells, and nanoparticles is noted for improving treatment effectiveness and inducing osteogenesis. Injectable hydrogels facilitate localized drug release, improve cell adhesion and proliferation, and support bone tissue regeneration, making them ideal candidates for peri-implantitis management. This review provides a detailed exploration of the physicochemical properties, cross-linking mechanisms, and responsiveness of injectable hydrogels to external stimuli, such as pH, temperature, and ionic strength. The goal of this review is to summaries the key components that are required for creating effective peri-implantitis targeting injectable hydrogels. The potential of injectable hydrogels for managing peri-implantitis by combating infection, inflammation, and tissue regeneration was especially discussed, as well as the challenges for constructing effective hydrogel, will be discussed. This work integrates material science with clinical dentistry for the first time to address peri-implantitis, providing actionable data for polymer chemists and clinicians by reviewing the latest advances in hydrogels, particularly injectable ones, for treating this common dental condition, while identifying gaps and proposing solutions for its prevention and treatment. © 2025 Elsevier B.V., All rights reserved.
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