Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels

Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels Publisher Pubmed

Mahmoudi Z¹ ; Mohammadnejad J¹ ; Razavi Bazaz S² ; Abouei Mehrizi A¹ ; Saidijam M³ ; Dinarvand R⁴ ; Ebrahimi Warkiani M^{2, 5} ; Soleimani M⁶

Show Affiliations

1. Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran
2. School of Biomedical Engineering, University of Technology Sydney, Sydney, 2007, NSW, Australia
3. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4. Nanotechnology Research Centre, Novel Drug Delivery Department, Faculty of Pharmacy, Tehran University of Medical Science, Tehran, Iran
5. Institute of Molecular Medicine, Sechenov University, Moscow, 119991, Russian Federation
6. Tissue engineering and Hematology Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Carbohydrate Polymers Published:2020

Abstract

The field of cartilage tissue engineering has been evolved in the last decade and a myriad of scaffolding biomaterials and bioactive agents have been proposed. Controlled release of growth factors encapsulated in the polymeric nanomaterials has been of interest notably for the repair of damaged articular cartilage. Here, we proposed an on-chip hydrodynamic flow focusing microfluidic approach for synthesis of alginate nanogels loaded with the transforming growth factor beta 3 (TGF-β3) through an ionic gelation method in order to achieve precise release profile of these bioactive agents during chondrogenic differentiation of mesenchymal stem cells (MSCs). Alginate nanogels with adjustable sizes were synthesized by fine-tuning the flow rate ratio (FRR) in the microfluidic device consisting of cross-junction microchannels. The result of present study showed that the proposed approach can be a promising tool to synthesize bioactive -loaded polymeric nanogels for applications in drug delivery and tissue engineering. © 2019

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Style	Citing Format
MLA	Mahmoudi Z, et al.. "Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels." Carbohydrate Polymers, vol. 229, no. , 2020, pp. -.
APA	Mahmoudi Z, Mohammadnejad J, Razavi Bazaz S, Abouei Mehrizi A, Saidijam M, Dinarvand R, Ebrahimi Warkiani M, Soleimani M (2020). Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels. Carbohydrate Polymers, 229(), -.
Chicago	Mahmoudi Z, Mohammadnejad J, Razavi Bazaz S, Abouei Mehrizi A, Saidijam M, Dinarvand R, Ebrahimi Warkiani M, Soleimani M. "Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels." Carbohydrate Polymers 229, no. (2020): -.
Harvard	Mahmoudi Z et al. (2020) 'Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels', Carbohydrate Polymers, 229(), pp. -.
Vancouver	Mahmoudi Z, Mohammadnejad J, Razavi Bazaz S, Abouei Mehrizi A, Saidijam M, Dinarvand R, et al.. Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels. Carbohydrate Polymers. 2020;229():-.
BibTex	@article{ author = {Mahmoudi Z and Mohammadnejad J and Razavi Bazaz S and Abouei Mehrizi A and Saidijam M and Dinarvand R and Ebrahimi Warkiani M and Soleimani M}, title = {Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels}, journal = {Carbohydrate Polymers}, volume = {229}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Mahmoudi Z AU - Mohammadnejad J AU - Razavi Bazaz S AU - Abouei Mehrizi A AU - Saidijam M AU - Dinarvand R AU - Ebrahimi Warkiani M AU - Soleimani M TI - Promoted Chondrogenesis of Hmcss With Controlled Release of Tgf-Β3 Via Microfluidics Synthesized Alginate Nanogels JO - Carbohydrate Polymers VL - 229 IS - SP - EP - PY - 2020 ER -

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