Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Relationship of Hip Fracture and Thyroid Disorders: A Systematic Review Publisher



Seyedalinaghi S1 ; Yarmohammadi S2 ; Dashti M3 ; Ghasemzadeh A3 ; Siami H4 ; Molla A5 ; Mahrokhi S1 ; Qaderi K6 ; Arjmand G7 ; Parikhani SN8 ; Amrollah MF1 ; Mirghaderi P9 ; Mehraeen E10 ; Dadras O11
Authors
Show Affiliations
Authors Affiliations
  1. 1. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Trauma Research Center, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. School of Medicine, Islamic Azad University of Medical Sciences, Tehran, Iran
  5. 5. School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  6. 6. Department of Midwifery, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran
  7. 7. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran
  11. 11. Bergen Addiction Research, Department of Addiction Medicine, Haukland University Hospital, Bergen, Norway

Source: Frontiers in Endocrinology Published:2023


Abstract

Introduction: Bone density regulation is considered one of the systems affected by thyroid hormones, leading to low bone density that can result in pathologic fractures, including hip fractures. This review aimed to update clinicians and researchers about the current data regarding the relationship between hip fractures and thyroid disorders. Methods: English papers were thoroughly searched in four main online databases of Scopus, Web of Science, PubMed, and Embase. Data extraction was done following two steps of screening/selection using distinct inclusion/exclusion criteria. This study used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist and the Newcastle-Ottawa Scale (NOS) as bias assessment. Results: In total, 19 articles were included in the research. The risk of hip fractures in women with differentiated thyroid cancer (DTC) is higher than hip fractures caused by osteoporosis. Men with hyperthyroidism and subclinical hyperthyroidism are at higher risk for hip fracture. Also, a decrease in serum thyroid stimulating hormone (TSH) may be associated with an increased risk of hip fracture. Conclusion: Reaching a consensus conclusion regarding the association between subclinical thyroid dysfunction and hip fracture is not feasible due to the heterogenicity of evidence; however, there may be a higher risk of fracture in individuals with subclinical hyperthyroidism. Copyright © 2023 SeyedAlinaghi, Yarmohammadi, Dashti, Ghasemzadeh, Siami, Molla, Mahrokhi, Qaderi, Arjmand, Parikhani, Amrollah, Mirghaderi, Mehraeen and Dadras.
Related Docs
1. Quantitative Ultrasound of Phalanx in Primary and Secondary Osteoporosis: Mini-Review and Practical Experience, Journal of Diagnostic Medical Sonography (2022)
Experts (# of related papers)
View all Related Experts
Mojtaba Sedaghat (1)
Sima Maziar (1)