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Communication Between Stromal and Hematopoietic Stem Cell by Exosomes in Normal and Malignant Bone Marrow Niche Publisher Pubmed



Niazi V1 ; Parseh B2 ; Ahani M1 ; Karami F1 ; Gilanchi S3 ; Atarodi K4 ; Soufi M5 ; Soleimani M5 ; Ghafourifard S6 ; Taheri M7 ; Zali H1, 8
Authors
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Authors Affiliations
  1. 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran
  2. 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 14177-55469, Iran
  3. 3. Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19716-53313, Iran
  4. 4. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, 14665-1157, Iran
  5. 5. Department of Hematology and Cell Therapy, Faculty of Medical Science, Tarbiat Modares University, Tehran, 14117-13116, Iran
  6. 6. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 19716-53313, Iran

Source: Biomedicine and Pharmacotherapy Published:2020


Abstract

Extracellular vesicles (EVs) have been regarded as important tools for cell-cell communication. They act as carriers for the transfer of various molecules such as genes, proteins and miRNA. EVs shift and transfer their ingredients to target cells in an active form. These particles have prominent roles in modulation of bone marrow (BM) niche; therefore they can regulate proliferation, differentiation, and other properties of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). This review discusses the different roles of EVs on BM niche; HPCs fate regulation and downstream effects of them on HSCs. Moreover, cellular and molecular mechanisms of BM microenvironment cross-talking are explained in healthy and malignant settings. © 2020
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