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Relationship Between Styrene Exposure and Prolactin Secretion in Human and Animal Studies: A Systematic Review Publisher Pubmed



Sadighara P1 ; Abedini A1 ; Zirak MR2 ; Salehi A1 ; Darbandi Azar S3 ; Mirzaei G1 ; Vakili Saatloo N4
Authors
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Authors Affiliations
  1. 1. Faculty of Public Health, Department of Environmental Health, Food Safety Division, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
  3. 3. Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Shaheed Beheshti University, Tehran, Iran
  4. 4. Faculty of Veterinary Medicine, Department of Food Hygiene and Quality Control, Urmia University, Urmia, Iran

Source: Human and Experimental Toxicology Published:2022


Abstract

Styrene is widely used in industrial applications. Inhalation exposure occurs in the industry. Some studies indicated that serum prolactin concentrations increased after exposure to styrene, while other studies found no change. In this systematic review, the search was done with the keywords styrene and prolactin in the PubMed, Science Direct, Web of Science and Scopus databases, regardless of the publication period. 118 studies were obtained and only seven articles were finally selected according to exclusion and inclusion criteria. The effect of styrene on prolactin secretion was selected in both human and animal studies. The increased response was seen in inhalation exposures. Subcutaneous exposure has no significant effect on prolactin levels. The observed responses were both dose-dependent and gender-dependent. Changes in serum prolactin were more frequent in women compared to exposed men. Dopamine depletion was not observed in all studies, so more tests on laboratory animals are necessary to clarify the possible mechanism. © The Author(s) 2022.
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