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Amino Acids Levels Related to Glutamine Supplementation for Type 2 Diabetes Patients Publisher



Mansour A1, 2 ; Hosseini S3 ; Qorbani M4, 5 ; Larijani B6 ; Mohajeritehrani MR3
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Authors Affiliations
  1. 1. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  5. 5. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Biomedical Research (India) Published:2018


Abstract

Aim: Amino acids levels are changed upon glutamine administration, but the impact of glutamine administration on plasma amino acid levels in type 2 diabetes patients remains unclear. Methods: A placebo controlled, randomized trial was performed with type 2 diabetic patients who consumed 2 supplements containing glutamine (10 g/3 times a day) or placebo (1 g/3 times a day) every day for 6 consecutive weeks. Blood samples were obtained just before initiation of study and again after the patients had received the study supplements. Results: Dietary supplementation with glutamine didn’t affect concentrations of plasma amino acid apart from for threonine. Plasma threonine concentration in intervention group was low at week 6 compared with placebo (glutamine group=111.19 ± 38.60 µmol/l, placebo group=135.30 ± 47.42 µmol/l; P=0.02). Conclusion: In type 2 diabetes patients, oral glutamine supplementation resulted in a decreased level of threonine. © 2018, Scientific Publishers of India. All rights reserved.
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