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Highlighted Gene Expression Alteration in Human Pancreatic Isolated Islets in Patients With Type 2 Diabetes Publisher



Mansouri V1 ; Arjmand B2, 3 ; Nejad MR4 ; Razzaghi Z5 ; Rezaeitavirani M1 ; Razi F6 ; Bandarian F7 ; Robati RM8 ; Rezaei M9, 10 ; Daneshimehr F11
Authors
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Authors Affiliations
  1. 1. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Iranian Cancer Control Center (MACSA), Tehran, Iran
  4. 4. Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  9. 9. Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  11. 11. InGeneron Company, Green Tower, Deireh, Dobai, 1304, United Arab Emirates

Source: Journal of Diabetes and Metabolic Disorders Published:2025


Abstract

Objectives: Type 2 diabetes is a complex disease characterized by progressive β-cell failure. The primary mechanism underlying this failure is the progressive loss of pancreatic β-cell function. The aim of this study is to identify the key gene expression changes in human pancreatic isolated islets of patients with type 2 diabetes. Methods: We extracted gene expression data in human pancreatic isolated islets of patients with type 2 diabetes and healthy controls from Gene Expression Omnibus (GEO) and analyzed it using GEO2R program. We then assessed the significant differentially expressed genes (DEGs) using protein-protein interaction (PPI) network analysis. The critical genes were enriched via gene ontology and discussed. Results: Among the 93 significant DEGs, five critical genes including ITGB2, APOE, BIRC5, GABRA2, and IL1B were emerged as key players in type 2 diabetes. Notably, “Alzheimer disease, type 4” was identified as a major class of biological terms altered in type 2 diabetes. Conclusions: Our findings suggest that the introduced critical genes are potential targets for controlling type 2 diabetes. Furthermore, the crucial role of APOE as a link between type 2 diabetes and Alzheimer’s disease or other cognitive disorders was confirmed. © The Author(s), under exclusive licence to Tehran University of Medical Sciences 2025.
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