Mitigating Effects of Rosemary and Salvia Officinalis Extracts on Oxidative Stress Induced by Chlorpyrifos and Deltamethrin in Serum Lipids of Wistar Rats Publisher



Samiei S¹ ; Pourbabaki R¹ ; Khadem M¹ ; Shahtaheri SJ² Show Affiliations
Source: Journal of Health System Research Published:2020

Abstract

Background: Chlorpyrifos and deltamethrin are organophosphorus and pyrethroid agents respectively, which can produce reactive oxygen species and oxidative stress. On the other hand, Rosemary and Salvia extracts contain antioxidants that play a protective role against free radicals. In this regard, the present study aimed to investigate the reduction effect of Rosemary and Salvia extract on the oxidative damage caused by the exposure to chlorpyrifos and deltamethrin. Methods: A total of 54 male Wistar rats weighing approximately 200-220 g were used in this study. The rats were randomly divided into nine groups (six rats in each group). The rats were weighed and sacrificed after 30 consecutive days of exposure, and serum samples were collected to examine the changes of malondialdehyde and glutathione peroxidase. Findings: Results of statistical tests showed that chlorpyrifos and deltamethrin significantly changed the levels of glutathione peroxidase activity and malondialdehyde in the exposed rat serums, compared to those in the control group. Moreover, simultaneous exposure to chlorpyrifos with Rosemary extract and deltamethrin with Salvia extract significantly decreased the levels of glutathione peroxidase and malondialdehyde and reduced the damage caused by these toxicants. Conclusion: According to the obtained results of this study, Rosemary and Salvia extracts can reduce the oxidative stress induced by chlorpyrifos and deltamethrin in Wistar rats. In addition, these extracts can be used to mitigate the consequences of poisoning caused by the pesticides of interest. © 2020, Isfahan University of Medical Sciences(IUMS). All rights reserved.