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Advice on Assistance and Protection Provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. on Medical Care and Treatment of Injuries From Nerve Agents Publisher Pubmed



Timperley CM1 ; Forman JE2 ; Abdollahi M3 ; Alamri AS4 ; Baulig A5 ; Benachour D6 ; Borrett V7, 8 ; Carino FA9 ; Geist M10 ; Gonzalez D11 ; Kane W12 ; Kovarik Z13 ; Martinezalvarez R14 ; Mourao NMF15 Show All Authors
Authors
  1. Timperley CM1
  2. Forman JE2
  3. Abdollahi M3
  4. Alamri AS4
  5. Baulig A5
  6. Benachour D6
  7. Borrett V7, 8
  8. Carino FA9
  9. Geist M10
  10. Gonzalez D11
  11. Kane W12
  12. Kovarik Z13
  13. Martinezalvarez R14
  14. Mourao NMF15
  15. Neffe S16
  16. Raza SK17
  17. Rubaylo V18
  18. Suarez AG19
  19. Takeuchi K20
  20. Tang C21
  21. Trifiro F22
  22. Van Straten FM23
  23. Vanninen PS24
  24. Vucinic S25
  25. Zaitsev V26, 27
  26. Zafaruzzaman M28
  27. Zina MS29
  28. Holen S30
Show Affiliations
Authors Affiliations
  1. 1. Defence Science and Technology Laboratory (Dstl), Porton Down, Salisbury, Wiltshire, United Kingdom
  2. 2. OPCW Scientific Advisory Board Secretary and Science Policy Adviser, The Organisation for the Prohibition of Chemical Weapons (OPCW), The Hague, Netherlands
  3. 3. Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), Department of Toxicology and Pharmacology, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Saudi Basic Industries Corporation (SABIC), Riyadh, Saudi Arabia
  5. 5. Secretariat General de la Defense et de la Securite Nationale (SGDSN), Paris, France
  6. 6. LMPMP, Faculty of Technology, Ferhat Abbas University, Setif-1, Algeria
  7. 7. BAI Scientific, Melbourne, Australia
  8. 8. University of Melbourne, Melbourne, Australia
  9. 9. University of the Philippines, Quezon City, Philippines
  10. 10. BASF SE, Ludwigshafen, Germany
  11. 11. Facultad de Quimica, Universidad de la Republica, Montevideo, Uruguay
  12. 12. Monsanto Company, LA, United States
  13. 13. Institute for Medical Research and Occupational Health, Zagreb, Croatia
  14. 14. Complutense University, Madrid, Spain
  15. 15. ABIQUIM, Brazilian Chemical Industry Association, Sao Paulo, Brazil
  16. 16. Military University of Technology, Warsaw, Poland
  17. 17. Institute of Pesticides Formulation Technology (IPFT), Gurugram, Haryana, India
  18. 18. State Scientific Research Institute of Organic Chemistry and Technology (GosNIIOKhT), Moscow, Russian Federation
  19. 19. Universidad Nacional de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Rosario, Argentina
  20. 20. National Institute of Advanced Industrial Science and Technology (AIST), Japan
  21. 21. Office for the Disposal of Japanese Abandoned Chemical Weapons, Ministry of National Defence, Beijing, China
  22. 22. Department of Industrial Chemistry, University of Bologna, Bologna, Italy
  23. 23. South African Nuclear Energy Corporation SOC Ltd., Pretoria, South Africa
  24. 24. VERIFIN, Department of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland
  25. 25. National Poison Control Centre, Military Medical Academy, Belgrade, Serbia
  26. 26. Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
  27. 27. Pontifical Catholic University of Rio de Janeiro, Brazil
  28. 28. National Engineering and Scientific Commission (NESCOM), Islamabad, Pakistan
  29. 29. Faculty of Sciences of Tunis (FST), Tunis, Tunisia
  30. 30. OPCW Scientific Advisory Board Secretary, 2011-2016, Netherlands

Source: Toxicology Published:2019


Abstract

The Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) has provided advice on assistance and protection in relation to the Chemical Weapons Convention. In this, the first of several papers describing the SAB's work on this topic, we describe advice given in response to questions from the OPCW Director-General in 2013 and 2014 on the status of available medical countermeasures and treatments to organophosphorus nerve agents. This paper provides the evidence base for this advice which recommended to the OPCW pretreatments, emergency care, and long-term treatments that were available at the time of the request for this class of chemical warfare agent (CWA). It includes a bibliography of over 140 scientific references, which can be used as a platform for watching future medical countermeasure developments. The information provided in this paper should serve as a valuable reference for medical professionals and emergency responders who may have no knowledge of the symptoms and treatment options of exposure to nerve agents. © 2019
6. Treatment of Organophosphorus Exposure and Precautions in Using Succinylcholine, Archives of Anesthesiology and Critical Care (2023)
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