Microstructural White Matter Alterations Associated With Migraine Headaches: A Systematic Review of Diffusion Tensor Imaging Studies

Microstructural White Matter Alterations Associated With Migraine Headaches: A Systematic Review of Diffusion Tensor Imaging Studies Publisher Pubmed

Rahimi R¹ ; Dolatshahi M¹ ; Abbasifeijani F² ; Momtazmanesh S¹ ; Cattarinussi G³ ; Aarabi MH³ ; Pini L³

Show Affiliations

1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. School of Medicine, Arak University of Medical Sciences, Tehran, Iran
3. Department of Neuroscience and Padova Neuroscience Center (PNC), University of Padova, Padua, Italy

Source: Brain Imaging and Behavior Published:2022

Abstract

The pathophysiology of migraine as a headache disorder is still undetermined. Diffusion tensor imaging (DTI) has significantly improved our knowledge about brain microstructure in this disease. Here, we aimed to systematically review DTI studies in migraine and survey the sources of heterogeneity by investigating diffusion parameter changes associated with clinical characteristics and migraine subtypes. Microstructural changes, as revealed by widespread alteration of diffusion metrics in white matter (WM) tracts, subcortical and cortical regions, were reported by several migraine DTI studies. Specifically, we reported changes in the corpus callosum, thalamic radiations, corona radiata, and brain stem. These alterations showed high variability across migraine cycle phases. Additionally, migraine associated with depressive/anxiety symptoms revealed significant changes in the corpus callosum, internal capsule, and superior longitudinal fasciculus. No significant WM microstructural differences were observed between migraine patients with and without aura. Overall, differences between chronic and episodic migraine showed inconsistency across studies. Migraine is associated with microstructural changes in widespread regions including thalamic radiations, corpus callosum, and brain stem. These alterations can highlight neuronal damage and neuronal plasticity mechanisms either following pain stimulations occurring in migraine cycle or as a compensatory response to pain in chronic migraine. Longitudinal studies applying advanced modalities may shed new light on the underlying microstructural changes in migraine subtypes. © 2022, The Author(s).

Related Docs

View other Related Docs

1. Structural and Functional Reorganization of the Brain in Migraine Without Aura, Frontiers in Neurology (2019)

2. Glia Signaling and Brain Microenvironment in Migraine, Molecular Neurobiology (2023)

3. Insights From Triggers and Prodromal Symptoms on How Migraine Attacks Start: The Threshold Hypothesis, Cephalalgia (2024)

4. Structural White Matter Alterations in Male Adults With High Functioning Autism Spectrum Disorder and Concurrent Depressive Symptoms; a Diffusion Tensor Imaging Study, Journal of Affective Disorders (2019)

5. Immunologic Aspects of Migraine: A Review of Literature, Frontiers in Neurology (2022)

6. Effects of Prenatal Methamphetamine Exposure on the Developing Human Brain: A Systematic Review of Neuroimaging Studies, ACS Chemical Neuroscience (2021)

7. Intact Microstructure of the Right Corticostriatal Pathway Predicts Creative Ability in Healthy Adults, Brain and Behavior (2020)

8. White Matter Microstructure Associated With the Antidepressant Effects of Deep Brain Stimulation in Treatment-Resistant Depression: A Review of Diffusion Tensor Imaging Studies, International Journal of Molecular Sciences (2022)

Experts (# of related papers)

Mansoureh Togha (2)

Abbas Tafakhori (1)

Style	Citing Format
MLA	Rahimi R, et al.. "Microstructural White Matter Alterations Associated With Migraine Headaches: A Systematic Review of Diffusion Tensor Imaging Studies." Brain Imaging and Behavior, vol. 16, no. 5, 2022, pp. 2375-2401.
APA	Rahimi R, Dolatshahi M, Abbasifeijani F, Momtazmanesh S, Cattarinussi G, Aarabi MH, Pini L (2022). Microstructural White Matter Alterations Associated With Migraine Headaches: A Systematic Review of Diffusion Tensor Imaging Studies. Brain Imaging and Behavior, 16(5), 2375-2401.
Chicago	Rahimi R, Dolatshahi M, Abbasifeijani F, Momtazmanesh S, Cattarinussi G, Aarabi MH, Pini L. "Microstructural White Matter Alterations Associated With Migraine Headaches: A Systematic Review of Diffusion Tensor Imaging Studies." Brain Imaging and Behavior 16, no. 5 (2022): 2375-2401.
Harvard	Rahimi R et al. (2022) 'Microstructural White Matter Alterations Associated With Migraine Headaches: A Systematic Review of Diffusion Tensor Imaging Studies', Brain Imaging and Behavior, 16(5), pp. 2375-2401.
Vancouver	Rahimi R, Dolatshahi M, Abbasifeijani F, Momtazmanesh S, Cattarinussi G, Aarabi MH, et al.. Microstructural White Matter Alterations Associated With Migraine Headaches: A Systematic Review of Diffusion Tensor Imaging Studies. Brain Imaging and Behavior. 2022;16(5):2375-2401.
BibTex	@article{ author = {Rahimi R and Dolatshahi M and Abbasifeijani F and Momtazmanesh S and Cattarinussi G and Aarabi MH and Pini L}, title = {Microstructural White Matter Alterations Associated With Migraine Headaches: A Systematic Review of Diffusion Tensor Imaging Studies}, journal = {Brain Imaging and Behavior}, volume = {16}, number = {5}, pages = {2375-2401}, year = {2022} }
RIS	TY - JOUR AU - Rahimi R AU - Dolatshahi M AU - Abbasifeijani F AU - Momtazmanesh S AU - Cattarinussi G AU - Aarabi MH AU - Pini L TI - Microstructural White Matter Alterations Associated With Migraine Headaches: A Systematic Review of Diffusion Tensor Imaging Studies JO - Brain Imaging and Behavior VL - 16 IS - 5 SP - 2375 EP - 2401 PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract