Post-Lasik Ectasia Versus Keratoconus: An in Vivo Confocal Microscopy Study

Post-Lasik Ectasia Versus Keratoconus: An in Vivo Confocal Microscopy Study Publisher Pubmed

Alvani A^{1, 2} ; Hashemi H² ; Pakravan M³ ; Mahbod M¹ ; Seyedian MA¹ ; Amanzadeh K⁴ ; Khabazkhoob M⁵ ; Jafarzadehpur E⁶ ; Fotouhi A⁷

Show Affiliations

1. Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran
2. Department of Ophthalmology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
5. Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Department of Optometry, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran
7. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Cornea Published:2020

Abstract

Purpose:To examine and compare corneal cellular and subbasal nerve (SBN) characteristics in post-laser-assisted in situ keratomileusis ectasia (PLE) corneas, normal post-laser-assisted in situ keratomileusis corneas (PLC), keratoconus (KC) corneas, and normal virgin corneas (NC).Methods:In this cross-sectional comparative study, 18 PLE eyes of 11 patients, 18 PLC of 15 cases, 32 KC eyes of 32 patients, and 29 NC of 29 subjects were assessed using in vivo confocal microscopy. The density of the basal epithelial cell (BEC), anterior keratocyte, posterior keratocyte, and endothelial cell layers, as well as the characteristics of SBN fibers, was compared between the 4 groups.Results:The density of the BEC and anterior and posterior keratocyte layers was significantly lower in KC compared with NC (-650 ± 190, P = 0.013; -181 ± 39, P < 0.001; and -36 ± 11, P = 0.021, respectively). However, there was no significant difference between PLE and PLC regarding these parameters (all Ps ≥ 0.6). Mean SBN parameters, including central corneal nerve branch density, nerve fiber length, total branch density, and nerve fiber area, were significantly lower in KC compared with NC and in PLE compared with PLC (all Ps ≤ 0.021).Conclusions:The pathophysiology of PLE seems to differ from KC. Apparent changes in the BEC and anterior and posterior keratocytes associated with KC were not observed in PLE. However, SBNs seem to be involved in both conditions. © 2020 Lippincott Williams and Wilkins. All rights reserved.

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Mehrdad Mohammadpour (2)

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Style	Citing Format
MLA	Alvani A, et al.. "Post-Lasik Ectasia Versus Keratoconus: An in Vivo Confocal Microscopy Study." Cornea, vol. 39, no. 8, 2020, pp. 1006-1012.
APA	Alvani A, Hashemi H, Pakravan M, Mahbod M, Seyedian MA, Amanzadeh K, Khabazkhoob M, Jafarzadehpur E, Fotouhi A (2020). Post-Lasik Ectasia Versus Keratoconus: An in Vivo Confocal Microscopy Study. Cornea, 39(8), 1006-1012.
Chicago	Alvani A, Hashemi H, Pakravan M, Mahbod M, Seyedian MA, Amanzadeh K, Khabazkhoob M, Jafarzadehpur E, Fotouhi A. "Post-Lasik Ectasia Versus Keratoconus: An in Vivo Confocal Microscopy Study." Cornea 39, no. 8 (2020): 1006-1012.
Harvard	Alvani A et al. (2020) 'Post-Lasik Ectasia Versus Keratoconus: An in Vivo Confocal Microscopy Study', Cornea, 39(8), pp. 1006-1012.
Vancouver	Alvani A, Hashemi H, Pakravan M, Mahbod M, Seyedian MA, Amanzadeh K, et al.. Post-Lasik Ectasia Versus Keratoconus: An in Vivo Confocal Microscopy Study. Cornea. 2020;39(8):1006-1012.
BibTex	@article{ author = {Alvani A and Hashemi H and Pakravan M and Mahbod M and Seyedian MA and Amanzadeh K and Khabazkhoob M and Jafarzadehpur E and Fotouhi A}, title = {Post-Lasik Ectasia Versus Keratoconus: An in Vivo Confocal Microscopy Study}, journal = {Cornea}, volume = {39}, number = {8}, pages = {1006-1012}, year = {2020} }
RIS	TY - JOUR AU - Alvani A AU - Hashemi H AU - Pakravan M AU - Mahbod M AU - Seyedian MA AU - Amanzadeh K AU - Khabazkhoob M AU - Jafarzadehpur E AU - Fotouhi A TI - Post-Lasik Ectasia Versus Keratoconus: An in Vivo Confocal Microscopy Study JO - Cornea VL - 39 IS - 8 SP - 1006 EP - 1012 PY - 2020 ER -

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