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White Matter Microstructural Differences Between Right and Left Mesial Temporal Lobe Epilepsy Publisher Pubmed



Sanjari Moghaddam H1 ; Rahmani F2, 3 ; Aarabi MH1 ; Nazemzadeh MR4 ; Davoodibojd E6 ; Soltanianzadeh H5, 6
Authors
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Authors Affiliations
  1. 1. Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. Student’s Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Science and Technology in Medicine (RCSTIM), Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, College of Engineering, University of Tehran, North Kargar Ave., Tehran, Iran
  6. 6. Image Analysis Laboratory, Departments of Radiology and Research Administration, Henry Ford Health System, One Ford Place, 2F, Detroit, 48202, MI, United States

Source: Acta Neurologica Belgica Published:2020


Abstract

Purpose: Mesial temporal lobe epilepsy (mTLE) is a chronic focal epileptic disorder characterized by recalcitrant seizures often necessitating surgical intervention. Identifying the laterality of seizure focus is crucial for pre-surgical planning. We implemented diffusion MRI (DMRI) connectometry to identify differences in white matter connectivity in patients with left and right mTLE relative to healthy control subjects. Method: We enrolled 12 patients with right mTLE, 12 patients with left mTLE, and 12 age/sex matched healthy controls (HCs). We used DMRI connectometry to identify local connectivity patterns of white matter tracts, based on quantitative anisotropy (QA). We compared QA of white matter to reconstruct tracts with significant difference in connectivity between patients and HCs and then between patients with left and right mTLE. Results: Right mTLE patients show higher anisotropy in left inferior longitudinal fasciculus (ILF) and forceps minor and lower QA in genu of corpus callosum (CC), bilateral corticospinal tracts (CSTs), and bilateral middle cerebellar peduncles (MCPs) compared to HCs. Left mTLE patients show higher anisotropy in genu of CC, bilateral CSTs, and right MCP and decreased anisotropy in forceps minor compared to HCs. Compared to patients with right mTLE, left mTLE patients showed increased and decreased connectivity in some major tracts. Conclusions: Our study showed the pattern of microstructural disintegrity in mTLE patients relative to HCs. We demonstrated that left and right mTLE patients have discrepant alternations in their white matter microstructure. These results may indicate that left and right mTLE have different underlying pathologic mechanisms. © 2019, Belgian Neurological Society.
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