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White Matter Correlates of Impulsive Behavior in Healthy Individuals: A Diffusion Magnetic Resonance Imaging Study Publisher



Rashidi F1 ; Parsaei M2 ; Kiani I1 ; Sadri A3, 4 ; Aarabi MH5, 6 ; Darijani SR1 ; Lee YS7, 8 ; Moghaddam HS9
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Breastfeeding Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Lyceum Scientific Charity, Tehran, Iran
  4. 4. Interdisciplinary Neuroscience Research Program, Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Neuroscience, University of Padova, Padova, Italy
  6. 6. Padova Neuroscience Center, University of Padova, Padova, Italy
  7. 7. School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United States
  8. 8. Department of Speech, Language, and Hearing, The University of Texas at Dallas, Richardson, TX, United States
  9. 9. Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Psychiatry and Clinical Neurosciences Reports Published:2024


Abstract

Aim: To explore white matter (WM) tracts linked to impulsivity using the diffusion magnetic resonance imaging (DMRI) connectometry method. Methods: We analyzed 218 healthy participants from the Leipzig Study for Mind-Body-Emotion Interactions database. Impulsivity correlations with DMRI-derived WM changes were assessed using Urgency-Premeditation-Perseverance-Sensation (UPPS) Impulsive Behavior Scale subscales: lack of perseverance (PE), lack of premeditation (PM), sensation seeking (SS), and negative urgency. DMRI data were processed using connectometry, adjusting for sex and age, to examine WM tract integrity via quantitative anisotropy (QA). Also, two additional interaction analyses were conducted to separately examine the interaction effect between WM QA, and sex and age in predicting impulsive behavior scores. The significance level in our statistical analyses was set at a false discovery rate (FDR) below 0.05. Results: QA in the bilateral cerebellum and middle cerebellar peduncle showed a negative association with PE and PM severity (FDR = 0.0004). QA in the middle cerebellar peduncle, corpus callosum body, and forceps major demonstrated a positive association with SS (FDR = 0.0001). Conversely, QA in forceps minor had a positive association with PM (FDR = 0.004), and QA in forceps minor and bilateral cingulum showed a positive association with SS (FDR = 0.0005). Age and sex had no significant effects on the association between WM QA and UPPS subscale scores. Conclusion: Impulsivity is linked to distinct WM integrity changes in various tracts, including the corpus callosum, cerebellum, and cingulum, offering insights into the pathophysiology of impulsivity and guiding future research. © 2024 The Author(s). Psychiatry and Clinical Neurosciences Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.
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