Staged Bilateral Laparoscopic Adrenalectomy for Infantile Acth-Independent Cushing's Syndrome (Bilateral Micronodular Non-Pigmented Adrenal Hyperplasia): A Case Report Pubmed



Simforoosh N¹ ; Azar MR^{2, 3} ; Soltani MH¹ ; Nourbakhsh M² ; Shemshaki H¹
Source: Urology Journal Published:2017

Abstract

ACTH-independent Cushing's syndrome is an uncommon disorder in children. While laparoscopic adrenalectomy is well-established in adults, it is rarely used in infants and is associated with some concerns. A seven-month infant was referred to our hospital due to progressive signs and symptoms of Cushing's syndrome. Laboratory data confirmed ACTH-independent hypercortisolism. No history of exogenous corticosteroid contact was observed. The patient underwent left transperitoneal laparoscopic adrenalectomy when she was 7 months old, nevertheless, complete response was not seen. The patient underwent right laparoscopic adrenalectomy (contra-lateral adrenal gland) when she was 20 months old. The signs and symptoms of Cushing's syndrome began to resolve and serum and urine cortisol levels became normal 3 months after the second surgery. laparoscopic adrenalectomy is safe and feasible in infants, and in this case, relieved patient of the symptoms and saved her life.